Accomplishments

Funded, 2024:

K23, NIA, Microglial Responses to Cell-free DNA in Alzheimer’s Disease. PI: Lolita Nidadavolu.

CFAR Scholar Award, CaMKII as a Driver of Chronic Inflammation and Sarcopenia in People Living with HIV. PI: Qinchuan Wang.

Johns Hopkins Catalyst Award (2024). PI: Jude Phillip.

Johns Hopkins Catalyst Award (2024). PI: Nicholas Rowan.

Funded, 2023:

Hevolution/AFAR New Investigator Awards in Aging Biology and Geroscience Research, Leveraging Kynurenine Pathway Manipulation to Improve Metabolic Dysfunction and Extend Healthspan in Mice. PI: Reyhan Westbrook.

R03, NIA, Cell-free DNA as a marker of progression in Alzheimer’s dementia and its role in chronic inflammation. PI: Lolita Nidadavolu.

K23, NIDDK, Addressing Inactive Kidney Transplant Waitlist Status through Adapting a Tailored Psycho-Social-Environmental Program. PI: Melissa Hladek.

Glenn and AFAR Junior Faculty Award, CaMKII as a Cause of Age-Related Sarcopenia. PI: Qinchuan Wang.

2023 Glenn and AFAR Junior Faculty Award, Deciphering functional subtypes of senescence at single-cell resolution. PI: Jude Phillip, PhD

Johns Hopkins University Center for AIDS Research (JHU CFAR), Developmental Core Award. PI: Nicholas Rowan.

Funded, 2022:

OAIC Supplement, NIA, Mitochondrial function, immune aging, and frailty among people with and without HIV.

K01, NIA, Alteration in the hypothalamic-pituitary-gonadal axis and frailty in aging men with HIV. PI: Jenny Pena Dias.

K01, NIA, The START trial: a proof-of-concept sedentary reduction program for prefrail older adults. PI: Amal Wanigatunga.

K01, NIA, Effects of Genetic and Pharmacological Kynurenine Pathway Suppression on Healthspan, Lifespan, and Cellular Changes Associated with Aging in Mice. PI: Reyhan Westbrook.

Funded, 2021:

K23, NIA, A Meal Delivery and Exercise Intervention to Increase Resilience in Homebound Older Adults. PI: Jessica Lee.

RF1, Cerebral Autoregulation in the Cardiac Surgery Intensive Care Unit: Associations with Postoperative Delirium, Cognitive Change, and Biomarkers of Brain Injury. PI: Charles Brown. 

P30, NIA, Utilizing Technology and AI Approaches to Facilitate Independence and Resilience in Older Adults. MPI: Chellappa, Abadir, Walston.

U01, NIAID,  Leveraging an ongoing longitudinal study of influenza vaccination to define immune signatures of response and risk of infection in older adults >75. PI: Sean Leng.

2021 Glenn and AFAR Junior Faculty Award, The role of IL-6 in promoting skeletal muscle and mitochondrial dysfunction in frailty. PI: Lolita Nidadavolu, MD, PhD

2021 Glenn and AFAR Junior Faculty Award, he Effects of Kynurenine Pathway Manipulation on Metabolism and Healthspan in Mice. PI: Reyhan Westbrook, PhD

Funded, 2020:

K01, NIA, Frailty, Post-Transplant Delirium, and Neurocognitive Underpinnings of Alzheimers. PI: Nadia Chu.

K23, NHLBI, Frailty and Resiliency in Older Adults with Acute Myocardial Infarction. PI: Abdulla Damluji.

R01, NIGMS, Differential Regulation and Roles of A-type Lamins in Early G1. PI: Katherine L. Wilson.

R13, NIA, Maximizing Inclusion of Researchers with Visual Impairments. PI: Bonnie Swenor.

Funded, 2019:

K23, NIA, Systemic- and Neuroinflammation and the Progression of Alzheimer’s Disease. PI: Keenan Walker. 

R01, NIA, Mitochondrial Energetics, Exercise Intolerance and Fatigability in Older People with HIV. PI: Robert Weiss.

R01 Diversity Supplement, NIA, Mitochondrial Energetics, Exercise Intolerance and Fatigability in Older People with HIV. PI: Sabra Lewsey.

Research to Prevent Blindness award, Wilmer Eye Institute, Cataract Surgery and Frailty. PI: Bonnie Swenor.

Johns Hopkins Catalyst Award, Improving postoperative outcomes for older adults. PI: Charles Brown.

Funded 2018:

K76 (Beeson), NIA, Improving Cancer Screening in Older Adults with Limited Life Expectancy. PI: Nancy Schoenborn.

K08, NIA, Alteration of Kynurenine Pathway in Age-Associated Muscle Weakness. PI: Tae Chung.

R01, NIA, Frailty, HIV Infection, Injection Drug Use, and the Inflammatory Microbiome. PI: Damani Piggott.

R01, NIA, Does Vestibular Loss Predict Falls in Patients with Alzheimer’s Disease? PI: Yuri Agrawal.

R01, NIA. ESRD-Specific Physiologic Age: Improving Geriatric Transplant Prognostication. PI: Mara McAdams-DeMarco.

Funded 2017 and earlier:

R21, NIA, Autoantibodies, Inflammation and Cognitive Decline. PI: Neal Fedarko.

UH2/UH3, NIA, Characterizing Resiliencies to Physical Stressors in Older Adults: A Dynamical Physiological Systems Approach. PIs: Jeremy Walston, Karen Bandeen-Roche, Ravi Varadhan.

U01, NIA, Energy Reserves, Physical Activity, and Alzheimer’s Disease in the Baltimore Longitudinal Study of Aging. PI: Jennifer Schrack.

R01, NIA, Enhancing Mobility in Older Adults by Treating Chronic Inflammation: Pilot Phase. PI: Jeremy Walston

R21, NIA, Recombinant Human Lactoferrin for the Treatment of Chronic Inflammation in Older Adults. PI: Jeremy Walston.

R21, NIA/NCI, Defining and Quantifying Fatigability in Functionally Independent Older Adults. PI: Jennifer Schrack.

K76 (Beeson), NIA, Monitoring Cerebral Autoregulation in Patients Undergoing Traumatic Hip Fracture Surgery to Improve Postoperative Outcomes. PI: Charles Brown.

K23, NIA, Association of Frailty with Post Thyroidectomy Alterations in Voice, Swallowing, and Quality of Life. PI: Aarti Mathur.

K23, NIA, Early Frailty Biomarkers: Patterns Of Activity and Energy Expenditure. PI: Megan Huisingh-Scheetz.

R03, NIA, Physical Frailty and Cognitive Impairment: Intersection, Measurement & Etiologies. PI: Qian-Li Xue

K01, NIA, Intersection of Physiologic Frailty and Cognitive Performance in Older Adults: An Integrative Data Analysis. PI: Alden Gross.

R01, NHLBI, Mitochondrial DNA Copy Number and Genetic Variation in Coronary Heart Disease. PI: Dan Arking.

RF1, NIA, Transitions To Family Caregiving and its Impact on Health Indicators. PI: David L. Roth.

R03, NIDDK, Lean Body Mass and the Development of Diabetes. PI: Rita Kaylani

2015 Glenn/AFAR Fellowship in Translational Research, The Identification and Translation of Novel Metabolic Findings in the Aging Chronically Inflammed Interleukin-10tm1Cgn Mouse. PI: Reyhan Westbrook

R03, NIA, Frailty Assessment: Matching Simplification Efforts to Clinical Aims. PI: Qian-Li Xue.

R21, NIA, Creating and Validating a Claims-based Indicator of Frailty. PI: Jodi Segal.

K23, NIDCD, Age-Related Changes in the Vestibular System and Functional Implications. PI: Yuri Agrawal

R01, NIAID, Influence Vaccine Failure in Adults Over Age 75: Role of Chronic CMV Infection. PI: Sean X Leng

K01, NIA, Frailty and Adverse Health Outcomes of Aging in Older Adults with Kidney Failure. PI: Mara McAdams DeMarco

K23, NIAID, Determinants and Consequences of Frailty among HIV-Infected Persons. PI: Damani Piggott

2013 Glenn Award for Research in Biological Mechanisms of Aging. PI: Jeremy Walston

R03, NIA, Clinical Significance of Short-Term Change and Variability of Grip Strength. PI: Qian-Li Xue

R21, NIA, Novel Formulation of Topical Losartan for Treatment of Wounds in Aging. PI: Jeremy Walston and Peter Abadir

P30, NIA, OAIC Renewal Grant. PI: Jeremy Walston; Co-PI: Karen Bandeen-Roche

K23, NIDDK, Glucose Insulin and Muscle Loss. PI: Rita Kalyani

Brookdale Leadership In Aging Award. PI: Ravi Varadhan

K23, NIDCD, Hearing Loss and Aging. PI: Frank R Lin

K23, NIA, Age Related Changes in Angiotensin Receptors and Its Role in Chronic Inflammation. PI: Peter Abadir

K23, NIA, CMV Infection and T-Cell Receptor Diversity in the Pathogenesis of Frailty. PI: George C Wang

R01, NIDDK, Mechanisms of Anemia of Chronic Inflammation and Aging in Mice. PI: Cindy N Roy

U01, NIA, PACTTE-Partnership for Anemia: Clinical and Translational Trials in the Elderly. PI: Harvey J Cohen; Sub-site PI: Jeremy Walston

K01, NIA, Aging-Related Biodemography of Life Course Physiology and Environmental Modifiers. PI: Christopher Seplaki

K23, NIA, Vaccine Induced Immunity Against Influenza in Frailty. PI: Sean X Leng

K23, NIA, Treatment Burden in Older Adults with Diabetes and Multimorbidity. PI: Cynthia M Boyd

2024

OAIC-supported presentations at the 2024 Annual Meeting of the Gerotological Society of America in Seattle, WA from November 13-16 include:

• “The Association of Peripheral and Central Olfaction With Frailty in Older Adults” (JGMS Editor’s Choice Articles of 2023: Risk and Recovery of Functional Decline and Frailty) by Nicholas Rowan, MD (REC Scholar) and colleagues
• “Free Testosterone, Sex Hormone Binding Globulin, and Incident Frailty in Men With HIV” by Jenny Pena Dias, PhD (REC Scholar and Pilot awardee) and colleagues
• Irving S. Wright Award Lecture: “Physical Frailty in Older Adults: What Drives and Prevents It?” by Jeremy Walston, MD (OAIC MPI)
• Symposium: “Advancements in Frailty Intervention Research: Current Trends and Future Directions” chaired by Qian-Li Xue, PhD (RC1 Core Leader). This symposium features a talk by Melissa Hladek, PhD (REC Scholar and Pilot Awardee) on “Empowering Frail Older Adults Through Digital Literacy: A Theory and Values-Based Intervention”
• “Cardiovascular-Derived Cell-Free DNA: Associations With Frailty and AgingRelated Comorbidities” by Lolita Nidadavolu, MD, PhD (REC Scholar) and colleagues
• “Characterization of Dynamic Adaptation to Stressors Using Multisystem Stimulus-Response Data” by Karen Bandeen-Roche, PhD (OAIC MPI, RC1 Co-Leader)
• The JHU Healthy Aging Studies Unit (supported by OAIC RC3) will be at booth #202 in the main exhibit hall. Please stop by!

2023

• At the 2023 Annual Meeting of the Gerontological Society of America in Tampa, FL, OAIC-supported presentations included: “Serum Concentrations of Losartan Metabolites Correlate With Improved Physical Function in a Pilot Study of Prefrail Older Adults” by Peter Abadir, MD (RC2 Core Leader; Pilot awardee); “Disentangl[ing] the Relation between Frailty, Self‐Rated Health, and Death: Implications for Resilience” by Chenkai Wu, PhD, MPH, MS; Qian-Li Xue, PhD (RC1 Core Leader); “Self‐Perception of Aging and the Self‐Reported Health/Frailty Paradox” by Brian Buta (OAIC administrator); and “Feasibility and Acceptability of a Depression and Pain Intervention With Older African American Women” by Janiece Taylor, PhD (Pilot awardee).
• At the 2023 International Conference on Frailty and Sarcopenia Research, held in Toulouse, France, Dr. Jeremy Walston led and presented at the symposium, “A Road Map for the Development of High Priority Physical Frailty Research;” Dr. Walston presented Biological Research Priorities, Dr. Qian-Li Xue presented Future Implementation Research Priorities, and Dr. Karen Bandeen-Roche presented Public Health Research Priorities. Also at this meeting, Dr. Xue led and presented at the symposium, “Disentangling Relationships among Resilience, Frailty, and Self-Reported Health: Longitudinal Evidence from Community and Clinical Studies of Older Adults,” with presentations by Brian Buta (Center Admin) and Amal Wanigatunga (Pilot awardee). Additionally, Dr. Karen Bandeen-Roche moderated a symposium on the Conceptualization, Ascertainment and Implications of Prefrailty as a Public Health Priority. Read more here: https://frailtyscience.org/blog/frailty-science-presentations-icfsr-2023

2022

• The JHU OAIC leadership helped to organized and present in the session, “Emerging Concepts in Aging Research: Frailty, and Reserve and Resilience” at the 2022 National Pepper Centers Annual Meeting.
• Dr. Qian-Li Xue led a symposium on “Frailty and Surgery: Integrating Evidence for Risk Prediction and Beyond” at the 2022 ICFSR conference.
• Drs. Bandeen-Roche and Xue presented at the cross-OAIC symposium, “Gerontologic Biostatistics: Merging with Data Science and Toward Personalized Medicine” at the 2022 Annual Meeting of the Gerontological Society of America.

2021

• The JHU OAIC led a virtual pre-conference workshop on “Moving Frailty into Clinical Practice: Successes, Challenges, and Lessons Learned Across Specialties” at the 2021 Annual Meeting of the Gerontological Society of America (GSA). This half-day workshop included a state-of-art overview of the conceptualization and definitions of frailty followed by presentations on progress-to-date in implementing frailty assessment into a wide variety of primary care and subspecialty settings, led by Drs. Jeremy Walston (Co-PI), Karen Bandeen-Roche (Co-PI), Qian-Li Xue (RC1 Leader), Abdulla Damluji (former REC), Mara McAdams-DeMarco (former REC/Pilot), Susan Gearhart (RC3 Development project investigator), Megan Huisingh-Scheetz (collaborator), and Brian Buta (Center Admin). 
• Dr. Bandeen-Roche organized and served as a discussant in a Roundtable Discussion session “‘Why’ rather than ‘How’: A Trans-Paradigmatic Discussion on the Urgency of the Frailty Concept for Optimizing Outcomes for Older Adults” with an international panel of frailty experts including Luigi Ferrucci, Susan Howlett, and Matteo Cesari, at the 2021 International Conference on Frailty and Sarcopenia Research (ICFSR).  Dr. Bandeen-Roche also chaired a symposium on “Resilience and Multifactorial Stressors among Older Adults during the COVID-19 Pandemic” at this meeting.

2020

• Dr. Xue led a virtual symposium on “Leveraging Existing Data from CMS-Linked Cohort Studies for the Advancement and Translation of Frailty Research” at the 2020 Annual Meeting of the Gerontological Society of America.

2019

• Dr. Xue led a symposium on “Latest Advances in Understanding the Relationships between Frailty and Cognitive Impairment” at the 2019 Annual Meeting of the Gerontological Society of America.
• Dr. Walston presented a keynote presentation on “Biomarkers and the Biology of Frailty” at the 2019 International Conference on Frailty and Sarcopenia Research.
• Dr. Bandeen-Roche led a symposium on: The Gap between Theory and Practice: A 360 Degree Consideration of Opportunities Remaining in Frailty Measurement” at the 2019 International Conference on Frailty and Sarcopenia Research. 

2018

• Dr. Walston led a symposium on “Metabolomic Signatures of Frailty” at the 2018 International Conference on Frailty and Sarcopenia Research in Miami. 
• Dr. Bandeen-Roche led a symposium on “Disparities in Frailty and Resiliency among Older Adults” at the 2018 Annual Meeting of the Gerontological Society of America in Boston.

2017

• Dr. Walston led a symposium, entitled “The Molecular and Organismal Basis of Resilience and Frailty” at the 21st IAGG World Congress of Gerontology and Geriatrics in San Francisco in July 2017.

2016

• Drs. Bandeen-Roche and Xue co-led, with Dr. Luigi Ferrucci, a symposium on “New Developments in Frailty Construct Validation: Move Beyond Predictive Validity,” at the 2016 Annual Meeting of the Gerontological Society of American in New Orleans, LA on November 17, 2016.
• Dr. Walston led a symposium on “A Mouse Model of Chronic Inflammation, Sarcopenia and Phenotypic Frailty,” at the 2016 International Conference on Frailty and Sarcopenia Research in Philadelphia PA on April 28, 2016.

2015

• “Disparities in Physical Functioning and Frailty among Older Americans: Findings from the NHATS,” at the 2015 Annual Meeting of the Gerontological Society of American in Orlando, FL on November 21, 2015.
• “Intersection and distinction between physical frailty and cognitive impairments among older adults” at the 2015 International Conference on Frailty and Sarcopenia Research in Boston in April 2015.

2014

• “Should Cognition be Included in the Assessment of Frailty?” at the 2014 Annual Meeting of the Gerontological Society of American in Washington, D.C. on November 8, 2014.
• “Towards the Integration of Frailty into Clinical Practice,” at the 2014 Annual Meeting of The American Geriatrics Society in Orlando, FL on May 15, 2014.
• “Beyond Epidemiological Risk Assessment: Frailty Syndrome Identification as the Key for Clinical Management, Biological Discovery, and Intervention Development” at the 2014 International Conference on Frailty and Sarcopenia Research in Barcelona, Spain in March 2014.
• 2014 Annual Meeting of the American Geriatrics Society, May 2014
• 2014 International Conference on Frailty and Sarcopenia Research, March 2014

2013

• “From Biology to Clinical Phenotype: Latest Findings in the Evolution of Frailty Research” at the 2013 Annual Meeting of the Gerontological Society of America in New Orleans
• 2013 Annual Meeting of the Gerontological Society of America, November 2013

2012

• Johns Hopkins / University of Maryland Pepper Centers Joint Symposia
• 2012 Annual Meeting of the Gerontological Society of America, November 2012

2024

Abadir P, Cosarderelioglu C, Damarla M, Malinina A, Dikeman D, Marx R, Nader MM, Abadir M, Walston J, Neptune E. Unlocking the protective potential of the angiotensin type 2 receptor (AT₂R) in acute lung injury and age-related pulmonary dysfunction. Biochem Pharmacol. 2024 Feb;220:115978. doi: 10.1016/j.bcp.2023.115978. Epub 2023 Dec 9. PMID: 38081369; PMCID: PMC10880333.

Bandeen-Roche, K. Frailty Measure Development, Selection, and Implications (Book Chapter). In Frailty: A Multidisciplinary Approach to Assessment, Management, and Prevention, Eds. J Ruiz & O. Theou. 2024, Springer, Cham. https://doi.org/10.1007/978-3-031-57361-3_17

Buta B, Twardzik E, Cudjoe T, Samuel L, Teano A, Langdon J, Thorpe R, Walston J, Xue QL. Social Determinants of Physical Frailty (Book Chapter). In Frailty: A Multidisciplinary Approach to Assessment, Management, and Prevention, Eds. J Ruiz & O. Theou. 2024, Springer, Cham. https://doi.org/10.1007/978-3-031-57361-3_50

Chen X, Chu NM, Thompson V, Quint EE, Alasfar S, Xue QL, Brennan DC, Norman SP, Lonze BE, Walston JD, Segev DL, McAdams-DeMarco MA. Development and Validation of an Abridged Physical Frailty Phenotype for Clinical Use: A Cohort Study Among Kidney Transplant Candidates. J Gerontol A Biol Sci Med Sci. 2024 Jan 1;79(1):glad173. doi: 10.1093/gerona/glad173. PMID: 37466327; PMCID: PMC10733181.

Cheng MZ, Vohra V, Wang H, Katuri A, Langdon JM, Xue QL, Rowan NR. The association between olfactory subdomains and frailty: A prospective case‒control study investigation. Int Forum Allergy Rhinol. 2024 Jun 28. doi: 10.1002/alr.23398. Epub ahead of print. PMID: 38940232.

Crepeau PK, Sutton W, Sahli Z, Fedorova T, Russell JO, Zeiger MA, Bandeen-Roche K, Walston JD, Morris-Wiseman LF, Mathur A. Prevalence and risk factors for dysphagia in older adults after thyroid and parathyroid surgery. Surgery. 2024 Jan;175(1):99-106. doi: 10.1016/j.surg.2023.04.066. Epub 2023 Nov 8. PMID: 37945476; PMCID: PMC10841879.

Fountain WA, Bopp TS, Bene M, Walston JD. Metabolic dysfunction and the development of physical frailty: an aging war of attrition. Geroscience. 2024 Feb 24. doi: 10.1007/s11357-024-01101-7. Epub ahead of print. PMID: 38400874.

Gabrawy MM, Westbrook R, King A, Khosravian N, Ochaney N, DeCarvalho T, Wang Q, Yu Y, Huang Q, Said A, Abadir M, Zhang C, Khare P, Fairman JE, Le A, Milne GL, Vonhoff FJ, Walston JD, Abadir PM. Dual treatment with kynurenine pathway inhibitors and NAD⁺ precursors synergistically extends life span in Drosophila. Aging Cell. 2024 Apr;23(4):e14102. doi: 10.1111/acel.14102. Epub 2024 Mar 13. PMID: 38481042; PMCID: PMC11019140.

Goeddel LA, Hernandez M, Koffman L, Slowey C, Muschelli J 3rd, Zhou X, Parikh CR, Lima JAC, Bandeen-Roche K, Faraday N, Crainiceanu CM, Brown Iv C. Assessment of Renal Vein Stasis Index by Transesophageal Echocardiography During Cardiac Surgery: A Feasibility Study. Anesth Analg. 2024 Sep 23. doi: 10.1213/ANE.0000000000007161. Epub ahead of print. PMID: 39312481.

Goeddel LA, Koffman L, Hernandez M, Whitman G, Parikh CR, Lima JAC, Bandeen-Roche K, Zhou X, Muschelli J 3rd, Crainiceanu C, Faraday N, Brown C 4th. Occurrence of Low Cardiac Index During Normotensive Periods in Cardiac Surgery: A Prospective Cohort Study Using Continuous Noninvasive Cardiac Output Monitoring. Anesth Analg. 2024 Aug 29. doi: 10.1213/ANE.0000000000007206. Epub ahead of print. PMID: 39207928.

Goeddel LA, Navarrete S, Waldron N, D’Amiano A, Faraday N, Lima JAC, Parikh CR, Bandeen-Roche K, Hays AG, Brown Iv C. Association between Left Ventricular Geometry, Systolic Ejection Time, and Estimated Glomerular Filtration Rate in Ambulatory Patients with Preserved Left Ventricular Ejection Fraction. Cardiology. 2024 Oct 1:1-11. doi: 10.1159/000541725. Epub ahead of print. PMID: 39353411.

Hladek MD, Wilson D, Krasnansky K, McDaniel K, Shanbhag M, McAdams-DeMarco M, Crews DC, Brennan DC, Taylor J, Segev D, Walston J, Xue QL, Szanton SL. Using Photovoice to Explore the Lived Environment and Experience of Older Adults with Frailty on their Kidney Transplant Journey. Kidney360. 2024 Feb 21. doi: 10.34067/KID.0000000000000380. Epub ahead of print. PMID: 38379153.

Kitzman DW, Halter JB, Bandeen-Roche K. The Pepper Older Americans Independence Centers: An NIA-sponsored program for improving physical function among older persons. J Am Geriatr Soc. 2024 May;72(5):1586-1589. doi: 10.1111/jgs.18866. Epub 2024 Mar 12. PMID: 38471899; PMCID: PMC11090727.

Kuhn PM, Chen S, Venkatraman A, Abadir PM, Walston JD, Kokkoli E. Co-Delivery of Valsartan and Metformin from a Thermosensitive Hydrogel-Nanoparticle System Promotes Collagen Production in Proliferating and Senescent Primary Human Dermal Fibroblasts. Biomacromolecules. 2024 Sep 9;25(9):5702-5717. doi: 10.1021/acs.biomac.3c01461. Epub 2024 Aug 26. PMID: 39186039.

Laskow T, Langdon J, Sepehri S, Davalos-Bichara M, Varadhan R, Walston J. Soluble TNFR1 has greater reproducibility than IL-6 for the assessment of chronic inflammation in older adults: the case for a new inflammatory marker in aging. Geroscience. 2024 Apr;46(2):2521-2530. doi: 10.1007/s11357-023-01006-x. Epub 2023 Nov 23. PMID: 37993568; PMCID: PMC10828298.

Liu F, Schrack JA, Walston J, Mathias RA, Windham BG, Grams ME, Coresh J, Walker KA. Mid-life plasma proteins associated with late-life prefrailty and frailty: a proteomic analysis. Geroscience. 2024 Jun 10. doi: 10.1007/s11357-024-01219-8. Epub ahead of print. PMID: 38856871.

Maity D, Sivakumar N, Kamat P, Zamponi N, Min C, Du W, Jayatilaka H, Johnston A, Starich B, Agrawal A, Riley D, Venturutti L, Melnick A, Cerchietti L, Walston J, Phillip JM. Profiling Dynamic Patterns of Single-Cell Motility. Adv Sci (Weinh). 2024 Oct;11(38):e2400918. doi: 10.1002/advs.202400918. Epub 2024 Aug 13. PMID: 39136147; PMCID: PMC11481225.

Sesso J, Walston J, Bandeen-Roche K, Wu C, Bertoni AG, Shah S, Lima JAC, Ambale-Venkatesh B. Association of cardiovascular fibrosis, remodeling, and dysfunction with frailty, pre-frailty, and functional performance: the Multi-Ethnic Study of Atherosclerosis (MESA). J Gerontol A Biol Sci Med Sci. 2024 May 25:glae142. doi: 10.1093/gerona/glae142. Epub ahead of print. PMID: 38795337.

Vohra V, Simonsick EM, Kamath V, Bandeen-Roche K, Agrawal Y, Rowan NR. Physical Function Trajectories and Mortality in Older Adults With Multisensory Impairment. JAMA Otolaryngol Head Neck Surg. 2024 Jan 18:e234378. doi: 10.1001/jamaoto.2023.4378. Epub ahead of print. PMID: 38236596; PMCID: PMC10797522.

Wu C, Xu Y, Tang J, Liu H, Xue QL. Joint Association of Physical Frailty and Self-Rated Health With Mortality Among Community-Dwelling Older Adults. J Gerontol A Biol Sci Med Sci. 2024 Apr 1;79(4):glad286. doi: 10.1093/gerona/glad286. PMID: 38153759.

Zandieh G, Afyouni S, Kato Y, Sesso J, Ortman J, Bandeen-Roche K, Walston J, Lima JAC, Ambale-Venkatesh B. Whole-Body MRI for Assessment of Physical Frailty. J Magn Reson Imaging. 2024 Oct 21. doi: 10.1002/jmri.29630. Epub ahead of print. PMID: 39429021.

2023

Assi S, Garcia Morales EE, Windham BG, Lin FR, Bandeen-Roche K, Shukla A, Palta P, Deal JA, Reed NS, Martinez-Amezcua P. Hearing Loss and Frailty among Older Adults: The Atherosclerosis Risk in Communities Study. J Am Med Dir Assoc. 2023 Nov;24(11):1683-1689.e5. doi: 10.1016/j.jamda.2023.08.023. Epub 2023 Sep 23. PMID: 37748754; PMCID: PMC10615781.

Bandeen-Roche K, Tian J, Buta B, Walston J, Xue QL. Substitution of self-reported measures for objectively assessed grip strength and slow walk in the Physical Frailty Phenotype: ramifications for validity. BMC Geriatr. 2023 Jul 22;23(1):451. doi: 10.1186/s12877-023-04105-8. PMID: 37481528; PMCID: PMC10362666.

Cannavo A, Jun S, Rengo G, Marzano F, Agrimi J, Liccardo D, Elia A, Keceli G, Altobelli GG, Marcucci L, Megighian A, Gao E, Feng N, Kammers K, Ferrara N, Finos L, Koch WJ, Paolocci N. β3AR-Dependent Brain-Derived Neurotrophic Factor (BDNF) Generation Limits Chronic Postischemic Heart Failure. Circ Res. 2023 Mar 31;132(7):867-881. doi: 10.1161/CIRCRESAHA.122.321583. Epub 2023 Mar 8. PMID: 36884028; PMCID: PMC10281793.

Chung T, Bopp T, Ward C, Notarangelo FM, Schwarcz R, Westbrook R, Xue QL, Walston J, Hoke A. Deletion of quinolinate phosphoribosyltransferase gene accelerates frailty phenotypes and neuromuscular decline with aging in a sex-specific pattern. Aging Cell. 2023 Apr 20:e13849. doi: 10.1111/acel.13849. Epub ahead of print. PMID: 37078472.

Cosarderelioglu C, Kreimer S, Plaza-Rodriguez AI, Iglesias PA, Talbot CC Jr, Siragy HM, Carey RM, Ubaida-Mohien C, O’Rourke B, Ferrucci L, Bennett DA, Walston J, Abadir P. Decoding Angiotensin Receptors: TOMAHAQ-Based Detection and Quantification of Angiotensin Type-1 and Type-2 Receptors. J Am Heart Assoc. 2023 Sep 19;12(18):e030791. doi: 10.1161/JAHA.123.030791. Epub 2023 Sep 8. PMID: 37681524; PMCID: PMC10547273.

Cosarderelioglu C, Nidadavolu LS, George CJ, Marx-Rattner R, Powell L, Xue QL, Tian J, Oh ES, Ferrucci L, Dincer P, Bennett DA, Walston JD, Abadir PM. Angiotensin receptor blocker use is associated with upregulation of the memory-protective angiotensin type 4 receptor (AT4R) in the postmortem brains of individuals without cognitive impairment. Geroscience. 2023 Feb;45(1):371-384. doi: 10.1007/s11357-022-00639-8. Epub 2022 Aug 15. PMID: 35969296; PMCID: PMC9886717.

Damluji AA, Ijaz N, Chung SE, Xue QL, Hasan RK, Batchelor WB, Orkaby AR, Kochar A, Nanna MG, Roth DL, Walston JD, Resar JR, Gerstenblith G. Hierarchical Development of Physical Frailty and Cognitive Impairment and Their Association With Incident Cardiovascular Disease. JACC Adv. 2023 May;2(3):100318. doi: 10.1016/j.jacadv.2023.100318. Epub 2023 May 10. PMID: 37538136; PMCID: PMC10399211.

Ducca EL, Gomez GT, Palta P, Sullivan KJ, Jack CR, Knopman DS, Gottesman RF, Walston J, Windham BG, Walker KA. Physical Frailty and Brain White Matter Abnormalities: The Atherosclerosis Risk in Communities Study. J Gerontol A Biol Sci Med Sci. 2023 Feb 24;78(2):357-364. doi: 10.1093/gerona/glac111. PMID: 35596270; PMCID: PMC9951053.

Elzamzami FD, Samal A, Arun AS, Dharmaraj T, Prasad NR, Rendon-Jonguitud A, DeVine L, Walston JD, Cole RN, Wilson KL. Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty. Front Cell Dev Biol. 2023 Oct 23;11:1240285. doi: 10.3389/fcell.2023.1240285. PMID: 37936983; PMCID: PMC10626543.

Ge ML, Chu NM, Simonsick EM, Kasper JD, Xue QL. Order of Onset of Physical Frailty and Cognitive Impairment and Risk of Repeated Falls in Community-Dwelling Older Adults. J Am Med Dir Assoc. 2023 Apr;24(4):482-488.e4. doi: 10.1016/j.jamda.2023.01.020. Epub 2023 Feb 25. PMID: 36852758; PMCID: PMC10167733.

Goeddel LA, Murphy Z, Owodunni O, Esfandiary T, Campbell D, Shay J, Tang O, Bandeen-Roche K, Gearhart S, Brown CH 4th. Domains of Frailty Predict Loss of Independence in Older Adults After Noncardiac Surgery. Ann Surg. 2023 Aug 1;278(2):e226-e233. doi: 10.1097/SLA.0000000000005720. Epub 2022 Sep 20. PMID: 36124773; PMCID: PMC10025167.

Ha NB, Seetharaman S, Kent DS, Yao F, Shui AM, Huang CY, Walston J, Lai JC. Serum and plasma protein biomarkers associated with frailty in patients with cirrhosis. Liver Transpl. 2023 Mar 20. doi: 10.1097/LVT.0000000000000128. Epub ahead of print. PMID: 36932707.

Hladek MD, Wilson DH, Shofner S, Gross AL, Buta B, Bandeen-Roche K, Schoenborn N. Resilient Adaptation Strategies: Unveiling Older Adults’ Coping Dynamics Amidst the COVID-19 Pandemic. J Gerontol Nurs. 2023 Dec;49(12):32-39. doi: 10.3928/00989134-20231108-04. Epub 2023 Dec 1. PMID: 38015152.

Liu F, Austin TR, Schrack JA, Chen J, Walston J, Mathias RA, Grams M, Odden MC, Newman A, Psaty BM, Ramonfaur D, Shah AM, Windham BG, Coresh J, Walker KA. Late-life plasma proteins associated with prevalent and incident frailty: A proteomic analysis. Aging Cell. 2023 Nov;22(11):e13975. doi: 10.1111/acel.13975. Epub 2023 Sep 11. PMID: 37697678; PMCID: PMC10652348.

Lu WH, Gonzalez-Bautista E, Guyonnet S, Lucas A, Parini A, Walston JD, Vellas B, de Souto Barreto P; MAPT/DSA Group. Plasma inflammation-related biomarkers are associated with intrinsic capacity in community-dwelling older adults. J Cachexia Sarcopenia Muscle. 2023 Apr;14(2):930-939. doi: 10.1002/jcsm.13163. Epub 2023 Jan 20. PMID: 36660894; PMCID: PMC10067471.

Mady LJ, De Ravin E, Vohra V, Lu J, Newman JG, Hall DE, Dalton PH, Rowan NR. Exploring Olfactory Dysfunction as a Marker of Frailty and Postoperative Outcomes in Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2023 Jul 27:e231935. doi: 10.1001/jamaoto.2023.1935. Epub ahead of print. PMID: 37498617; PMCID: PMC10375382.

Nader MM, Cosarderelioglu C, Miao E, Whitson H, Xue QL, Grodstein F, Oh E, Ferrucci L, Bennett DA, Walston JD, George C, Abadir PM. Navigating and diagnosing cognitive frailty in research and clinical domains. Nat Aging. 2023 Nov;3(11):1325-1333. doi: 10.1038/s43587-023-00504-z. Epub 2023 Oct 16. PMID: 37845509.

Nagururu NV, Bernstein IA, Voegtline K, Olson S, Agrawal Y, Rowan NR. The Association of Peripheral and Central Olfaction With Frailty in Older Adults. J Gerontol A Biol Sci Med Sci. 2023 Jul 8;78(7):1276-1283. doi: 10.1093/gerona/glac237. PMID: 36502375; PMCID: PMC10329228.

Nidadavolu LS, Cosarderelioglu C, Merino Gomez A, Wu Y, Bopp T, Zhang C, Nguyen T, Marx-Rattner R, Yang H, Antonescu C, Florea L, Talbot CC, Smith B, Foster DB, Fairman JE, Yenokyan G, Chung T, Le A, Walston JD, Abadir PM. Interleukin-6 Drives Mitochondrial Dysregulation and Accelerates Physical Decline: Insights from an Inducible Humanized IL-6 Knock-In Mouse Model. J Gerontol A Biol Sci Med Sci. 2023 Jun 13:glad147. doi: 10.1093/gerona/glad147. Epub ahead of print. PMID: 37310873.

Nidadavolu LS, Feger D, Chen D, Wu Y, Grodstein F, Gross AL, Bennett DA, Walston JD, Oh ES, Abadir PM. Associations between circulating cell-free mitochondrial DNA, inflammatory markers, and cognitive and physical outcomes in community dwelling older adults. Immun Ageing. 2023 May 23;20(1):24. doi: 10.1186/s12979-023-00342-y. PMID: 37221566; PMCID: PMC10204157.

Pharoah BM, Zhang C, Khodade VS, Keceli G, McGinity C, Paolocci N, Toscano JP. Hydropersulfides (RSSH) attenuate doxorubicin-induced cardiotoxicity while boosting its anticancer action. Redox Biol. 2023 Apr;60:102625. doi: 10.1016/j.redox.2023.102625. Epub 2023 Feb 4. PMID: 36773545; PMCID: PMC9929489

Rubin DS, Xue QL. Interaction Between Frailty and Dementia. JAMA Surg. 2023 Apr 5. doi: 10.1001/jamasurg.2023.0378. Epub ahead of print. PMID: 37017961.

Saraswathula A, Schlosser RJ, Rowan NR. Reimbursement for Olfactory Testing: A Growing Need at a Unique Time in History. JAMA Otolaryngol Head Neck Surg. 2023 Jul 1;149(7):567-568. doi: 10.1001/jamaoto.2023.0837. PMID: 37166819.

Taylor JL, Clair CA, Gitlin LN, Atkins S, Bandeen-Roche K, Abshire Saylor M, Hladek MD, Riser TJ, Thorpe RJ Jr, Szanton SL. Acceptability and Feasibility of a Pain and Depressive Symptoms Management Intervention in Middle-Aged and Older African American Women. Innov Aging. 2023 Sep 8;7(10):igad096. doi: 10.1093/geroni/igad096. PMID: 38094930; PMCID: PMC10714909.

Taylor JL, Clair CA, Lee JW, Atkins S, Riser TJ, Szanton SL, McCoy MC, Thorpe RJ Jr, Wang C, Gitlin LN. A protocol for a wait list control trial of an intervention to improve pain and depressive symptoms among middle-aged and older African American women. Contemp Clin Trials. 2023 Sep;132:107299. doi: 10.1016/j.cct.2023.107299. Epub 2023 Jul 20. PMID: 37478967; PMCID: PMC10527967.

Taylor KS, Umeukeje EM, Santos SR, McNabb KC, Crews DC, Hladek MD. Context Matters: A Qualitative Synthesis of Adherence Literature for People on Hemodialysis. Kidney360. 2023 Jan 1;4(1):41-53. doi: 10.34067/KID.0005582022. PMID: 36700903; PMCID: PMC10101575.

Walston J, Varadhan R, Xue QL, Buta B, Sieber F, Oni J, Imus P, Crews DC, Artz A, Schrack J, Kalyani RR, Abadir P, Carlson M, Hladek M, McAdams-DeMarco M, Jones R, Johnson A, Shafi T, Newman AB, Bandeen-Roche K. A Study of Physical Resilience and Aging (SPRING): Conceptual framework, rationale, and study design. J Am Geriatr Soc. 2023 Jun 30. doi: 10.1111/jgs.18483. Epub ahead of print. PMID: 37386913.

Wanigatunga AA, Chiu V, Cai Y, Urbanek JK, Mitchell CM, Miller ER 3rd, Christenson RH, Rebuck H, Michos ED, Juraschek SP, Walston J, Xue QL, Bandeen-Roche K, Appel LJ, Schrack JA. Patterns of Daily Physical Movement, Chronic Inflammation, and Frailty Incidence. Med Sci Sports Exerc. 2023 Feb 1;55(2):281-288. doi: 10.1249/MSS.0000000000003048. Epub 2022 Sep 29. PMID: 36170549; PMCID: PMC9840658.

Wunderlich B, Laskow T, Li H, Zhang L, Abrams E, Tian J, Yu J, Chen Y, Tavenier J, Huang Y, Talaat K, Bream JH, Xue QL, Pawelec G, Leng SX. Interseason waning of vaccine-induced hemagglutination inhibition antibody titers and contributing factors to pre-existing humoral immunity against influenza in community-dwelling older adults 75 years and older. Immun Ageing. 2023 Jul 31;20(1):38. doi: 10.1186/s12979-023-00362-8. PMID: 37525151; PMCID: PMC10388475.

Yesantharao LV, Vohra V, Cheng M, Simonsick EM, Agrawal Y, du Lac S, Rowan NR. Olfactory Dysfunction and Balance Dysfunction are Associated with Increased Falls in Older Adults. Laryngoscope. 2023 Aug;133(8):1964-1969. doi: 10.1002/lary.30733. Epub 2023 May 9. PMID: 37159236.

2022

Armstrong ND, Irvin MR, Haley WE, Blinka MD, Kamin Mukaz D, Patki A, Rutherford Siegel S, Shalev I, Durda P, Mathias RA, Walston JD, Roth DL. Telomere shortening and the transition to family caregiving in the Reasons for Geographic and Racial Differences in Stroke (REGARDS) study. PLoS One. 2022 Jun 3;17(6):e0268689. doi: 10.1371/journal.pone.0268689. PMID: 35657918; PMCID: PMC9165822.

Buta B, Friedman AB, Chung SE, Sheehan OC, Blinka MD, Gearhart SL, Xue QL. The combined effects of physical frailty and cognitive impairment on emergency department- versus direct-admission hospitalizations. BMC Geriatr. 2022 Aug 31;22(1):718. doi: 10.1186/s12877-022-03397-6. PMID: 36042414; PMCID: PMC9429704.

Buta B, Zheng S, Langdon J, Adeosun B, Bandeen-Roche K, Walston JD, Xue QL. Agreement between standard and self-reported assessments of physical frailty syndrome and its components in a registry of community-dwelling older adults. BMC Geriatrics. 2022. Accepted for publication.

Cai Y, Wanigatunga AA, Mitchell CM, Urbanek JK, Miller ER 3rd, Juraschek SP, Michos ED, Kalyani RR, Roth DL, Appel LJ, Schrack JA. The effects of vitamin D supplementation on frailty in older adults at risk for falls. BMC Geriatr. 2022 Apr 10;22(1):312. doi: 10.1186/s12877-022-02888-w. PMID: 35399053; PMCID: PMC8994906.

Chen X, Shafaat O, Liu Y, King EA, Weiss CR, Xue QL, Walston JD, Segev DL, McAdams-DeMarco MA. Revision of frailty assessment in kidney transplant recipients: Replacing unintentional weight loss with CT-assessed sarcopenia in the physical frailty phenotype. Am J Transplant. 2022 Apr;22(4):1145-1157. doi: 10.1111/ajt.16934. Epub 2022 Jan 8. PMID: 34953170; PMCID: PMC8983565.

Chu NM, Ruck J, Chen X, Xue QL, Norman SP, Segev DL, McAdams-DeMarco MA. Long-term Trajectories of Frailty and its Components after Kidney Transplantation. J Gerontol A Biol Sci Med Sci. 2022 Feb 20:glac051. doi: 10.1093/gerona/glac051. Epub ahead of print. PMID: 35184167.

Clegg A, Bandeen-Roche K, Farrin A, Forster A, Gill TM, Gladman J, Kerse N, Lindley R, McManus RJ, Melis R, Mujica-Mota R, Raina P, Rockwood K, Teh R, van der Windt D, Witham M. New horizons in evidence-based care for older people: individual participant data meta-analysis. Age Ageing. 2022 Apr 1;51(4):afac090. doi: 10.1093/ageing/afac090. PMID: 35460409; PMCID: PMC9034697.

Cosarderelioglu C, Nidadavolu LS, George CJ, Marx R, Powell L, Xue QL, Tian J, Salib J, Oh E, Ferrucci L, Dincer P, Bennett DA, Walston JD, Abadir PM. Higher Angiotensin II type 1 receptor (AT1R) levels and activity in the post-mortem brains of older persons with Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2022 Apr 1;77(4):664-672. doi: 10.1093/gerona/glab376. PMID: 34914835.

Drazich BF, Jenkins E, Nkimbeng M, Abshire Saylor M, Szanton SL, Wright R, Beach MC, Taylor JL. Exploring the Experiences of Co-morbid Pain and Depression in Older African American Women and Their Preferred Management Strategies. Front Pain Res (Lausanne). 2022 Feb 28;3:845513. doi: 10.3389/fpain.2022.845513. PMID: 35295801; PMCID: PMC8915555.

Ducca EL, Gomez GT, Palta P, Sullivan KJ, Jack CR, Knopman DS, Gottesman RF, Walston J, Windham BG, Walker KA. Physical Frailty and Brain White Matter Abnormalities: The ARIC Study. J Gerontol A Biol Sci Med Sci. 2022 May 21:glac111. doi: 10.1093/gerona/glac111. Epub ahead of print. PMID: 35596270.

Gabrawy MM, Khosravian N, Morcos GS, Morozova TV, Jezek M, Walston JD, Huang W, Abadir PM, Leips J. Genome-Wide Analysis in Drosophila Reveals the Genetic Basis of Variation in Age-Specific Physical Performance and Response to ACE Inhibition. Genes (Basel). 2022 Jan 14;13(1):143. doi: 10.3390/genes13010143. PMID: 35052483; PMCID: PMC8775566.

Huq S, Liu J, Romano R, Seal S, Khalafallah AM, Walston JD, Mukherjee D. Frailty in Patients Undergoing Surgery for Brain Tumors: A Systematic Review of the Literature. World Neurosurg. 2022 Jul 14:S1878-8750(22)00986-X. doi: 10.1016/j.wneu.2022.07.039. Epub ahead of print. PMID: 35843574.

Ijaz N, Buta B, Xue QL, Mohess DT, Bushan A, Tran H, Batchelor W, deFilippi CR, Walston JD, Bandeen-Roche K, Forman DE, Resar JR, O’Connor CM, Gerstenblith G, Damluji AA. Interventions for Frailty Among Older Adults With Cardiovascular Disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2022 Feb 8;79(5):482-503. doi: 10.1016/j.jacc.2021.11.029. PMID: 35115105; PMCID: PMC8852369.

Keceli G, Gupta A, Sourdon J, Gabr R, Schär M, Dey S, Tocchetti CG, Stuber A, Agrimi J, Zhang Y, Leppo M, Steenbergen C, Lai S, Yanek LR, O’Rourke B, Gerstenblith G, Bottomley PA, Wang Y, Paolocci N, Weiss RG. Mitochondrial Creatine Kinase Attenuates Pathologic Remodeling in Heart Failure. Circ Res. 2022 Mar 4;130(5):741-759. doi: 10.1161/CIRCRESAHA.121.319648. Epub 2022 Feb 3. PMID: 35109669; PMCID: PMC8897235.

Lee JL, Zhang C, Westbrook R, Gabrawy MM, Nidadavolu L, Yang H, Marx R, Wu Y, Anders NM, Ma L, Bichara MD, Kwak MJ, Buta B, Khadeer M, Yenokyan G, Tian J, Xue QL, Siragy HM, Carey RM, de Cabo R, Ferrucci L, Moaddel R, Rudek MA, Le A, Walston JD, Abadir PM. Serum concentrations of losartan metabolites correlate with improved physical function in a pilot study of prefrail older adults. J Gerontol A Biol Sci Med Sci. 2022 May 3:glac102. doi: 10.1093/gerona/glac102. Epub ahead of print. PMID: 35511890.

Maity D, Kamat P, Zamponi N, Jayatilaka H, Giri A, Du W, Johnston A, Starich B, Karl M, Agrawal A, Riley D, Venturutti L, Melnick A, Cerchietti L, Walston J, Phillip JM. Profiling emergent behaviors from single-cell motility. bioRxiv 2022.09.21.508955; doi: https://doi.org/10.1101/2022.09.21.508955

Marin S, Godet I, Nidadavolu LS, Tian J, Dickinson LE, Walston JD, Gilkes DM, Abadir PM. Valsartan and sacubitril combination treatment enhances collagen production in older adult human skin cells. Exp Gerontol. 2022 May 19:111835. doi: 10.1016/j.exger.2022.111835. Epub ahead of print. PMID: 35598697.

Palta P, Griswold M, Ranadive R, Bandeen-Roche K, Folsom AR, Petruski-Ivleva N, Burgard S, Kucharska-Newton A, Windham BG. Midlife Cardiovascular Health and Robust Versus Frail Late-Life Status: The Atherosclerosis Risk in Communities Study. J Gerontol A Biol Sci Med Sci. 2022 Jun 1;77(6):1222-1229. doi: 10.1093/gerona/glab310. PMID: 34661638; PMCID: PMC9159655.

Phillip JM, Lin R, Cheetham A, Stern D, Li Y, Wang Y, Wang H, Rini D, Cui H, Walston JD, Abadir PM. Nature-inspired delivery of mitochondria-targeted angiotensin receptor blocker. PNAS Nexus, 2022; pgac147. https://doi.org/10.1093/pnasnexus/pgac147

Roth DL, Bentley JP, Mukaz DK, Haley WE, Walston JD, Bandeen-Roche K. Transitions to Family Caregiving and Latent Variables of Systemic Inflammation Over Time. Res Aging. 2022 Apr 15:1640275221084729. doi: 10.1177/01640275221084729. Epub ahead of print. PMID: 35422166.

Saleh N, Cosarderelioglu C, Vajapey R, Walston J, Abadir P. Losartan Mitigates Oxidative Stress in the Brains of Aged and Inflamed IL10 -/- Mice. J Gerontol A Biol Sci Med Sci. 2022 Apr 29:glac101. doi: 10.1093/gerona/glac101. Epub ahead of print. PMID: 35486382.

Sezgin D, O’Donovan M, Woo J, Bandeen-Roche K, Liotta G, Fairhall N, Rodríguez-Laso A, Apóstolo J, Clarnette R, Holland C, Roller-Wirnsberger R, Illario M, Mañas LR, Vollenbroek-Hutten M, Doğu BB, Balci C, Pernas FO, Paul C, Ahern E, Romero-Ortuno R, Molloy W, Cooney MT, O’Shea D, Cooke J, Lang D, Hendry A, Kennelly S, Rockwood K, Clegg A, Liew A, O’Caoimh R. Early identification of frailty: Developing an international delphi consensus on pre-frailty. Arch Gerontol Geriatr. 2022 Mar-Apr;99:104586. doi: 10.1016/j.archger.2021.104586. Epub 2021 Nov 20. PMID: 34896797.

Vohra V, Leland EM, Schlosser RJ, Kamath V, Rowan NR. Association of Frailty Status and Dietary Patterns in a Nationally Representative Sample of United States Adults with Olfactory Dysfunction. Nutrients. 2022 Mar 15;14(6). doi: 10.3390/nu14061238. PubMed PMID: 35334897; PubMed Central PMCID: PMC8954153.

2021

Blinka MD, Buta B, Bader KD, Hanley C, Schoenborn NL, McNabney M, Xue QL. Developing a sensor-based mobile application for in-home frailty assessment: a qualitative study. BMC Geriatr. 2021 Feb 4;21(1):101. doi: 10.1186/s12877-021-02041-z.

Chan T, Wanigatunga AA, Terracciano A, Carlson MC, Bandeen-Roche K, Costa PT, Simonsick EM, Schrack JA. Traits and treadmills: Association between personality and perceived fatigability in well-functioning community-dwelling older adults. Psychol Aging. 2021 Sep;36(6):710-717. doi: 10.1037/pag0000631. PMID: 34516174; PMCID: PMC8442749.

Chhetri JK, Xue QL, Ma L, Chan P, Varadhan R. Intrinsic Capacity as a Determinant of Physical Resilience in Older Adults. J Nutr Health Aging. 2021;25(8):1006-1011. doi: 10.1007/s12603-021-1629-z. PubMed PMID: 34545921; PubMed Central PMCID: PMC8035602.

Chu NM, Bandeen-Roche K, Xue QL, Carlson MC, Sharrett AR, Gross AL. Physical Frailty Phenotype Criteria and Their Synergistic Association on Cognitive Functioning. J Gerontol A Biol Sci Med Sci. 2021 Aug 13;76(9):1633-1642. doi: 10.1093/gerona/glaa267.

Chu NM, Xue QL, McAdams-DeMarco MA, Carlson MC, Bandeen-Roche K, Gross AL. Frailty-a risk factor of global and domain-specific cognitive decline among a nationally representative sample of community-dwelling older adult U.S. Medicare beneficiaries. Age Ageing. 2021 Sep 11;50(5):1569-1577. doi: 10.1093/ageing/afab102. PMID: 34097002; PMCID: PMC8437073.

Damluji AA, Chung SE, Xue QL, Hasan RK, Walston JD, Forman DE, Bandeen-Roche K, Moscucci M, Batchelor W, Resar JR, Gerstenblith G. Physical Frailty Phenotype and the Development of Geriatric Syndromes in Older Adults with Coronary Heart Disease. Am J Med. 2021 May;134(5):662-671.e1. doi: 10.1016/j.amjmed.2020.09.057.  PMCID: PMC8107119.

Damluji AA, Chung SE, Xue QL, Hasan RK, Moscucci M, Forman DE, Bandeen-Roche K, Batchelor W, Walston JD, Resar JR, Gerstenblith G. Frailty and cardiovascular outcomes in the National Health and Aging Trends Study. Eur Heart J. 2021 Oct 1;42(37):3856-3865. doi: 10.1093/eurheartj/ehab468. PMID: 34324648; PMCID: PMC8487013.

Fried LP, Cohen AA, Xue QL, Walston J, Bandeen-Roche K, Varadhan R. The physical frailty syndrome as a transition from homeostatic symphony to cacophony. Nat Aging 2021;1:36–46. https://doi.org/10.1038/s43587-020-00017-z. PMCID: PMC8409463.

Ge ML, Simonsick EM, Dong BR, Kasper JD, Xue QL. Frailty, with or without Cognitive Impairment, is a Strong Predictor of Recurrent Falls in a US Population-Representative Sample of Older Adults. J Gerontol A Biol Sci Med Sci. 2021 Mar 15:glab083. doi: 10.1093/gerona/glab083. Epub ahead of print. PMID: 33721909.

Ghachem A, Fried LP, Legault V, Bandeen-Roche K, Presse N, Gaudreau P, Cohen AA. Evidence from two cohorts for the frailty syndrome as an emergent state of parallel dysregulation in multiple physiological systems. Biogerontology. 2021 Feb;22(1):63-79. doi: 10.1007/s10522-020-09903-w. Epub 2020 Oct 16. PMID: 33064226; PMCID: PMC8557952.

Haugen CE, Gross A, Chu NM, Norman SP, Brennan DC, Xue QL, Walston J, Segev DL, McAdams-DeMarco M. Development and Validation of an Inflammatory-Frailty Index for Kidney Transplantation. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):470-477. doi: 10.1093/gerona/glaa167. PMCID: PMC7907494.

Hladek MD, Zhu J, Buta BJ, Szanton SL, Bandeen-Roche K, Walston JD, Xue QL. Self-efficacy proxy predicts frailty incidence over time in non-institutionalized older adults. J Am Geriatr Soc. 2021 Dec;69(12):3507-3518. doi: 10.1111/jgs.17417. Epub 2021 Aug 21. PMID: 34418062; PMCID: PMC8648965.

Huisingh-Scheetz M, Buta B, Bandeen-Roche K, Huang ES, Varadhan R, Walston J, Wroblewski K, Schumm LP, Waite LJ. 2015-2016 Normative Data for the 3-m Usual Walk, Five Repeated Chair Stands, and Static Balance Components of the SPPB Among U.S. Older Adults Across Two Nationally Representative Data Sets: NSHAP and NHATS. J Gerontol B Psychol Sci Soc Sci. 2021 Dec 17;76(Supplement_3):S299-S312. doi: 10.1093/geronb/gbab135. PMID: 34918153; PMCID: PMC8678433.

Laskow T, Langdon J, Abadir P, Xue QL, Walston J. Lactoferrin for the treatment of age-associated inflammation – A pilot study. Physiol Int. 2021 Apr 9;. doi: 10.1556/2060.2021.00010. [Epub ahead of print]

Ma L, Nidadavolu LS, Yang H, Langdon J, Westbrook R, Tsui BMW, Lee TS, Hinson J, Ling S, Marx-Rattner R, Wu Y, Nguyen T, Tan J, Khadeer M, Moaddel R, Le A, Walston JD, Abadir PM. Targeted Deletion of Interleukin-6 in a Mouse Model of Chronic Inflammation Demonstrates Opposing Roles in Aging: Benefit and Harm. J Gerontol A Biol Sci Med Sci. 2021 Jan 18;76(2):211-215. doi: 10.1093/gerona/glaa156. PMCID: PMC7812426.

Nidadavolu LS, Walston JD. Underlying Vulnerabilities to the Cytokine Storm and Adverse COVID-19 Outcomes in the Aging Immune System. J Gerontol A Biol Sci Med Sci. 2021 Feb 25;76(3):e13-e18. doi: 10.1093/gerona/glaa209.  PMCID: PMC7546042.

Nidadavolu LS, Stern D, Lin R, Wang Y, Li Y, Wu Y, Marin S, Antonio MJ, Yenokyan G, Boronina T, Cole R, Foster DB, Talbot C, Jedrych J, Smith B, Rini D, Le A, Cui H, Walston JD, Abadir PM. Valsartan nano-filaments alter mitochondrial energetics and promote faster healing in diabetic rat wounds. Wound Repair Regen. 2021 Nov;29(6):927-937. doi: 10.1111/wrr.12974. Epub 2021 Oct 20. PMID: 34669222

Phillip JM, Zamponi N, Phillip MP, Daya J, McGovern S, Williams W, Tschudi K, Jayatilaka H, Wu PH, Walston J, Wirtz D. Fractional re-distribution among cell motility states during ageing. Commun Biol. 2021 Jan 19;4(1):81. doi: 10.1038/s42003-020-01605-w. PMID: 33469145; PMCID: PMC7815872.

Phillip JM, Han KS, Chen WC, Wirtz D, Wu PH. A robust unsupervised machine-learning method to quantify the morphological heterogeneity of cells and nuclei. Nat Protoc. 2021 Feb;16(2):754-774. doi: 10.1038/s41596-020-00432-x. PMCID: PMC8167883.

Usher T, Buta B, Thorpe RJ, Huang J, Samuel LJ, Kasper JD, Bandeen-Roche K. Dissecting the Racial/Ethnic Disparity in Frailty in a Nationally Representative Cohort Study with Respect to Health, Income, and Measurement. J Gerontol A Biol Sci Med Sci. 2021 Jan 1;76(1):69-76. doi: 10.1093/gerona/glaa061. PMID: 32147727; PMCID: PMC7756712.

Wanigatunga AA, Cai Y, Urbanek JK, Mitchell CM, Roth DL, Miller ER, Michos ED, Juraschek SP, Walston J, Xue QL, Appel LJ, Schrack JA. Objectively measured patterns of daily physical activity and phenotypic frailty. J Gerontol A Biol Sci Med Sci. 2021 Sep 25:glab278. doi: 10.1093/gerona/glab278. Epub ahead of print. PMID: 34562073.

Westbrook R, Zhang C, Yang H, Tian J, Gui S, Xue QL, Walston J, Le A, Abadir PM. Metabolomics-based Identification of Metabolic Dysfunction in Frailty. J Gerontol A Biol Sci Med Sci. 2021; glab315, https://doi.org/10.1093/gerona/glab315 Xue QL, Bandeen-Roche K, Tian J, Kasper JD, Fried LP. Progression of Physical Frailty and the Risk of All-Cause Mortality: Is There a Point of No Return?. J Am Geriatr Soc. 2021 Apr;69(4):908-915. doi: 10.1111/jgs.16976.

2020

Bandeen-Roche K, Gross AL, Varadhan R, Buta B, Carlson MC, Huisingh-Scheetz M, Mcadams-Demarco M, Piggott DA, Brown TT, Hasan RK, Kalyani RR, Seplaki CL, Walston JD, Xue QL. Principles and Issues for Physical Frailty Measurement and Its Clinical Application. J Gerontol A Biol Sci Med Sci. 2020 May 22;75(6):1107-1112. doi: 10.1093/gerona/glz158. PMID: 31287490; PMCID: PMC7243579.

Chu NM, Chen X, Norman SP, Fitzpatrick J, Sozio SM, Jaar BG, Frey A, Estrella MM, Xue QL, Parekh RS, Segev DL, McAdams-DeMarco MA. Frailty Prevalence in Younger End-Stage Kidney Disease Patients Undergoing Dialysis and Transplantation. Am J Nephrol. 2020;51(7):501-510. doi: 10.1159/000508576. Epub 2020 Jul 8. PMID: 32640462; PMCID: PMC7442041.

Damluji AA, Rodriguez G, Noel T, Davis L, Dahya V, Tehrani B, Epps K, Sherwood M, Sarin E, Walston J, Bandeen-Roche K, Resar JR, Brown TT, Gerstenblith G, O’Connor CM, Batchelor W. Sarcopenia and health-related quality of life in older adults after transcatheter aortic valve replacement. Am Heart J. 2020 Jun;224:171-181. doi: 10.1016/j.ahj.2020.03.021. Epub 2020 Apr 4. PMID: 32416332.

Ge ML, Carlson MC, Bandeen-Roche K, Chu NM, Tian J, Kasper JD, Xue QL. U.S. National Profile of Older Adults with Cognitive Impairment Alone, Physical Frailty Alone, and Both. J Am Geriatr Soc. 2020 Aug 28. doi: 10.1111/jgs.16769. Epub ahead of print. PMID: 32860219.

Gross AL, Carlson MC, Chu NM, McAdams-DeMarco MA, Mungas D, Simonsick EM, Varadhan R, Xue QL, Walston J, Bandeen-Roche K. Derivation of a measure of physiological multisystem dysregulation: Results from WHAS and health ABC. Mech Ageing Dev. 2020 Jun;188:111258. doi: 10.1016/j.mad.2020.111258. Epub 2020 May 11. PMID: 32423871; PMCID: PMC7375911.

Guralnik J, Bandeen-Roche K, Bhasin SAR, Eremenco S, Landi F, Muscedere J, Perera S, Reginster JY, Woodhouse L, Vellas B. Clinically Meaningful Change for Physical Performance: Perspectives of the ICFSR Task Force. J Frailty Aging. 2020;9(1):9-13. doi: 10.14283/jfa.2019.33. PMID: 32150208; PMCID: PMC7286121.

Harhay MN, Rao MK, Woodside KJ, Johansen KL, Lentine KL, Tullius SG, Parsons RF, Alhamad T, Berger J, Cheng XS, Lappin J, Lynch R, Parajuli S, Tan JC, Segev DL, Kaplan B, Kobashigawa J, Dadhania DM, McAdams-DeMarco MA. An overview of frailty in kidney transplantation: measurement, management and future considerations. Nephrol Dial Transplant. 2020 Jul 1;35(7):1099-1112. doi: 10.1093/ndt/gfaa016. PMID: 32191296; PMCID: PMC7417002.

Haugen CE, Gross A, Chu NM, Norman SP, Brennan DC, Xue QL, Walston J, Segev DL, McAdams-DeMarco M. Development and validation of an inflammatory-frailty index for kidney transplantation. J Gerontol A Biol Sci Med Sci. 2020 Jul 3:glaa167. doi: 10.1093/gerona/glaa167. Epub ahead of print. PMID: 32619229.

Lee MJ, Varadaraj V, Tian J, Bandeen-Roche K, Swenor BK. The Association between Frailty and Uncorrected Refractive Error in Older Adults. Ophthalmic Epidemiol. 2020 Jun;27(3):219-225. doi: 10.1080/09286586.2020.1716380. Epub 2020 Jan 17. PMID: 31952461; PMCID: PMC7080595.

Leucker TM, Schulman SP, Gerstenblith G. Stable ischemic heart disease: how to keep it that way. J Clin Invest. 2020 Mar 2;130(3):1055-1057. doi: 10.1172/JCI135959. PMID: 31985489; PMCID: PMC7269554.

Lewsey SC, Weiss K, Schär M, Zhang Y, Bottomley PA, Samuel TJ, Xue QL, Steinberg A, Walston J, Gerstenblith G, Weiss RG. Exercise intolerance and rapid skeletal muscle energetic decline in human age-associated frailty. JCI Insight. 2020 Sep 17:141246. doi: 10.1172/jci.insight.141246. Epub ahead of print. PMID: 32941181.

Li Y, Xue QL, Odden MC, Chen X, Wu C. Linking early life risk factors to frailty in old age: evidence from the China Health and Retirement Longitudinal Study. Age Ageing. 2020 Feb 27;49(2):208-217. doi: 10.1093/ageing/afz160. PMID: 31957780; PMCID: PMC7047816.

Longchamps RJ, Castellani CA, Yang SY, Newcomb CE, Sumpter JA, Lane J, Grove ML, Guallar E, Pankratz N, Taylor KD, Rotter JI, Boerwinkle E, Arking DE. Evaluation of mitochondrial DNA copy number estimation techniques. PLoS One. 2020 Jan 31;15(1):e0228166. doi: 10.1371/journal.pone.0228166. PMID: 32004343; PMCID: PMC6994099.

Malinina A, Dikeman D, Westbrook R, Moats M, Gidner S, Poonyagariyagorn H, Walston J, Neptune ER. IL10 deficiency promotes alveolar enlargement and lymphoid dysmorphogenesis in the aged murine lung. Aging Cell. 2020 Apr;19(4):e13130. doi: 10.1111/acel.13130. Epub 2020 Mar 14. PMID: 32170906; PMCID: PMC7189990.

McAdams-DeMarco MA, Van Pilsum Rasmussen SE, Chu NM, Agoons D, Parsons RF, Alhamad T, Johansen KL, Tullius SG, Lynch R, Harhay MN, Rao MK, Berger J, Cooper M, Tan JC, Cheng XS, Woodside KJ, Parajuli S, Lentine KL, Kaplan B, Segev DL, Kobashigawa JA, Dadhania D; AST Kidney Pancreas Community of Practice Workgroup. Perceptions and Practices Regarding Frailty in Kidney Transplantation: Results of a National Survey. Transplantation. 2020 Feb;104(2):349-356. doi: 10.1097/TP.0000000000002779. PMID: 31343576; PMCID: PMC6834867.

Nakano M, Nomura Y, Suffredini G, Bush B, Tian J, Yamaguchi A, Walston J, Hasan R, Mandal K, Schena S, Hogue CW, Brown CH 4th. Functional Outcomes of Frail Patients After Cardiac Surgery: An Observational Study. Anesth Analg. 2020 Jun;130(6):1534-1544. doi: 10.1213/ANE.0000000000004786. PMID: 32384343.

Piggott DA, Bandeen-Roche K, Mehta SH, Brown TT, Yang H, Walston JD, Leng SX, Kirk GD. Frailty transitions, inflammation, and mortality among persons aging with HIV infection and injection drug use. AIDS. 2020 Jul 1;34(8):1217-1225. doi: 10.1097/QAD.0000000000002527. PMID: 32287069.

Roth DL, Haley WE, Sheehan OC, Huang J, Rhodes JD, Durda P, Howard VJ, Walston JD, Cushman M. The transition to family caregiving and its effect on biomarkers of inflammation. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16258-16263. doi: 10.1073/pnas.2000792117. Epub 2020 Jun 24. PMID: 32581123; PMCID: PMC7368336.

Roth DL, Haley WE, David Rhodes J, Sheehan OC, Huang J, Blinka MD, Yuan Y, Irvin MR, Jenny N, Durda P, Cushman M, Walston JD, Howard VJ. Transitions to family caregiving: enrolling incident caregivers and matched non-caregiving controls from a population-based study. Aging Clin Exp Res. 2020 Sep;32(9):1829-1838. doi: 10.1007/s40520-019-01370-9. Epub 2019 Oct 19. PMID: 31630377.

Sonsin-Diaz N, Gottesman RF, Fracica E, Walston J, Windham BG, Knopman DS, Walker KA. Chronic Systemic Inflammation Is Associated With Symptoms of Late-Life Depression: The ARIC Study. Am J Geriatr Psychiatr, 2020 January;28(1):87-98. PubMed PMID: 31182350; PubMed Central PMCID: PMC6868307; DOI: 10.1016/j.jagp.2019.05.011.

Swenor BK, Lee MJ, Tian J, Varadaraj V, Bandeen-Roche K. Visual Impairment and Frailty: Examining an Understudied Relationship. J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):596-602. doi: 10.1093/gerona/glz182. PMID: 31419280; PMCID: PMC7328203.

Van Domelen D, Bandeen-Roche K. A Note on Proposed Estimation Procedures for Claims-Based Frailty Indexes. Am J Epidemiol. 2020 May 5;189(5):369-371. doi: 10.1093/aje/kwz247. PMID: 31673711; PMCID: PMC7413045.

Van Pilsum Rasmussen SE, Warsame F, Eno AK, Ying H, Covarrubias K, Haugen CE, Chu NM, Crews DC, Harhay MN, Schoenborn NL, Segev DL, McAdams-DeMarco MA. Perceptions, Barriers, and Experiences With Successful Aging Before and After Kidney Transplantation: A Focus Group Study. Transplantation. 2020 March;104(3):603-612. PubMed PMID: 31283666; PubMed Central PMCID: PMC6930354; DOI: 10.1097/TP.0000000000002848.

Walker KA, Gross AL, Moghekar AR, Soldan A, Pettigrew C, Hou X, Lu H, Alfini AJ, Bilgel M, Miller MI, Albert MS, Walston J. Association of peripheral inflammatory markers with connectivity in large-scale functional brain networks of non-demented older adults. Brain Behav Immun. 2020 Jul;87:388-396. doi: 10.1016/j.bbi.2020.01.006. Epub 2020 Jan 11. PMID: 31935468; PMCID: PMC7316598.

Westbrook R, Chung T, Lovett J, Ward C, Joca H, Yang H, Khadeer M, Tian J, Xue QL, Le A, Ferrucci L, Moaddel R, de Cabo R, Hoke A, Walston J, Abadir PM. Kynurenines link chronic inflammation to functional decline and physical frailty. JCI Insight. 2020 Aug 20;5(16):e136091. doi: 10.1172/jci.insight.136091. PMID: 32814718; PMCID: PMC7455140.

Wu PH, Gilkes DM, Phillip JM, Narkar A, Cheng TW, Marchand J, Lee MH, Li R, Wirtz D. Single-cell morphology encodes metastatic potential. Sci Adv. 2020 Jan 22;6(4):eaaw6938. doi: 10.1126/sciadv.aaw6938. PMID: 32010778; PMCID: PMC6976289.

Yasar S, Moored KD, Adam A, Zabel F, Chuang YF, Varma VR, Carlson MC. Angiotensin II Blood Levels Are Associated with Smaller Hippocampal and Cortical Volumes in Cognitively Normal Older Adults. J Alzheimers Dis. 2020;75(2):521-529. doi: 10.3233/JAD-200118. PMID: 32280103; PMCID: PMC7293768.

2019

Chu NM, Bandeen-Roche K, Tian J, Kasper JD, Gross AL, Carlson M, Xue QL. Hierarchical Development of Frailty and Cognitive Impairment: Clues into Etiological Pathways. J Gerontol A Biol Sci Med Sci. 2019 Oct 4;74(11):1761-1770. doi: 10.1093/gerona/glz134.

Chu NM, Deng A, Ying H, Haugen CE, Garonzik Wang JM, Segev DL, McAdams-DeMarco MA. Dynamic Frailty Before Kidney Transplantation-Time of Measurement Matters. Transplantation. 2019 Aug;103(8):1700-1704. doi: 10.1097/TP.0000000000002563.

Chu NM, Gross AL, Shaffer AA, Haugen CE, Norman SP, Xue QL, Sharrett AR, Carlson MC, Bandeen-Roche K, Segev DL, McAdams-DeMarco MA. Frailty and Changes in Cognitive Function after Kidney Transplantation. J Am Soc Nephrol. 2019 Feb;30(2):336-345. doi: 10.1681/ASN.2018070726. Epub 2019 Jan 24.

Damluji AA, Huang J, Bandeen-Roche K, Forman DE, Gerstenblith G, Moscucci M, Resar JR, Varadhan R, Walston JD, Segal JB. Frailty Among Older Adults With Acute Myocardial Infarction and Outcomes From Percutaneous Coronary Interventions. J Am Heart Assoc. 2019 Sep 3;8(17):e013686. doi: 10.1161/JAHA.119.013686. Epub 2019 Aug 31. PMID: 31475601; PMCID: PMC6755849.

Damluji AA, Bandeen-Roche K, Berkower C, Boyd CM, Al-Damluji MS, Cohen MG, Forman DE, Chaudhary R, Gerstenblith G, Walston JD, Resar JR, Moscucci M. Percutaneous Coronary Intervention in Older Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock. J Am Coll Cardiol. 2019 Apr 23;73(15):1890-1900. doi: 10.1016/j.jacc.2019.01.055. PMID: 30999991; PMCID: PMC7185801.

Fitzpatrick J, Sozio SM, Jaar BG, Estrella MM, Segev DL, Parekh RS, McAdams-DeMarco MA. Frailty, body composition and the risk of mortality in incident hemodialysis patients: the Predictors of Arrhythmic and Cardiovascular Risk in End Stage Renal Disease study. Nephrol Dial Transplant. 2019 Feb 1;34(2):346-354. doi: 10.1093/ndt/gfy124.

Gabrawy MM, Campbell S, Carbone MA, Morozova TV, Arya GH, Turlapati LB, Walston JD, Starz-Gaiano M, Everett L, Mackay TFC, Leips J, Abadir PM. Lisinopril Preserves Physical Resilience and Extends Life Span in a Genotype-Specific Manner in Drosophila melanogaster. J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(12):1844-1852. doi: 10.1093/gerona/glz152. PMID: 31197356; PMCID: PMC7329186.

Gross AL, Walker KA, Moghekar AR, Pettigrew C, Soldan A, Albert MS, Walston JD. Plasma Markers of Inflammation Linked to Clinical Progression and Decline During Preclinical AD. Front Aging Neurosci. 2019 Sep 6;11:229. doi: 10.3389/fnagi.2019.00229. PMID: 31555121; PMCID: PMC6742958.

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, Fuldner R, Ferrucci L, Gallicchio L, Gavrilov L, Gavrilova N, Green PA, Jhappan C, Kohanski R, Krull K, Mandelblatt J, Ness KK, O’Mara A, Price N, Schrack J, Studenski S, Theou O, Tracy RP, Hurria A. Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. J Natl Cancer Inst. 2019 Dec 1;111(12):1245-1254. doi: 10.1093/jnci/djz136. PMID: 31321426.

Haugen CE, Chu NM, Ying H, Warsame F, Holscher CM, Desai NM, Jones MR, Norman SP, Brennan DC, Garonzik-Wang J, Walston JD, Bingaman AW, Segev DL, McAdams-DeMarco M. Frailty and Access to Kidney Transplantation. Clin J Am Soc Nephrol. 2019 Apr 5;14(4):576-582. doi: 10.2215/CJN.12921118. Epub 2019 Mar 19. PMID: 30890577; PMCID: PMC6450348.

Hladek MD, Gill J, Bandeen-Roche K, Walston J, Allen J, Hinkle JL, Lorig K, Szanton SL. High coping self-efficacy associated with lower odds of pre-frailty/frailty in older adults with chronic disease. Aging Ment Health. 2019 Jul 10:1-7. doi: 10.1080/13607863.2019.1639136. Epub ahead of print. PMID: 31290680.

Hurria A, Carpenter CR, McFarland F, Lundebjerg NE, de Cabo R, Ferrucci L, Studenski SA, Barzilai N, Briggs JP, Ix JH, Kitzman DW, Kuchel GA, Musi N, Newman JC, Rando TA, Smith AK, Walston JD, Kirkland JL, Yung R. Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series. J Am Geriatr Soc. 2019 Mar;67(3):428-433. doi: 10.1111/jgs.15788. Epub 2019 Jan 29.

Janssen EM, Pollack CE, Boyd C, Bridges JFP, Xue QL, Wolff AC, Schoenborn NL. How Do Older Adults Consider Age, Life Expectancy, Quality of Life, and Physician Recommendations When Making Cancer Screening Decisions? Results from a National Survey Using a Discrete Choice Experiment. Med Decis Making. 2019 Aug;39(6):621-631. doi: 10.1177/0272989X19853516. Epub 2019 Jun 21. PMID: 31226903; PMCID: PMC7080208.

McAdams-DeMarco MA, Ying H, Van Pilsum Rasmussen S, Schrack J, Haugen CE, Chu NM, González Fernández M, Desai N, Walston JD, Segev DL. Prehabilitation prior to kidney transplantation: Results from a pilot study. Clin Transplant. 2019 Jan;33(1):e13450. doi: 10.1111/ctr.13450. Epub 2018 Dec 21.

Nomura Y, Nakano M, Bush B, Tian J, Yamaguchi A, Walston J, Hasan R, Zehr K, Mandal K, LaFlam A, Neufeld KJ, Kamath V, Hogue CW, Brown CH 4th. Observational Study Examining the Association of Baseline Frailty and Postcardiac Surgery Delirium and Cognitive Change. Anesth Analg. 2019 Aug;129(2):507-514. doi: 10.1213/ANE.0000000000003967. PMID: 30540612; PMCID: PMC7243370.

Pérez Fernández M, Martínez Miguel P, Ying H, Haugen CE, Chu NM, Rodríguez Puyol DM, Rodríguez-Mañas L, Norman SP, Walston JD, Segev DL, McAdams-DeMarco MA. Comorbidity, Frailty, and Waitlist Mortality among Kidney Transplant Candidates of All Ages. Am J Nephrol. 2019;49(2):103-110. doi: 10.1159/000496061. Epub 2019 Jan 9.

Qiao Y, Martinez-Amezcua P, Wanigatunga AA, Urbanek JK, Simonsick EM, Ferrucci L, Schrack JA. Association Between Cardiovascular Risk and Perceived Fatigability in Mid-to-Late Life. J Am Heart Assoc. 2019 Aug 20;8(16):e013049. doi: 10.1161/JAHA.119.013049. Epub 2019 Aug 14. PMID: 31409206; PMCID: PMC6759892.

Rebok GW, Parisi JM, Barron JS, Carlson MC, Diibor I, Frick KD, Fried LP, Gruenewald TL, Huang J, McGill, S, Ramsey CM, Romani WA, Seeman TE, Tan E, Tanner EK, Xing L, Xue QL. (in press).  Impact of Experience Corps® participation on children’s academic achievement and school behavior.  Prev Sci. 2019 Jan 10. doi: 10.1007/s11121-018-0972-8. [Epub ahead of print] PMID: 30627854.

Roth DL, Sheehan OC, Haley WE, Jenny NS, Cushman M, Walston JD. Is Family Caregiving Associated With Inflammation or Compromised Immunity? A Meta-Analysis. Gerontologist. 2019 Sep 17;59(5):e521-e534. doi: 10.1093/geront/gnz015. PMID: 30852588; PMCID: PMC6857696.

Rout A, Madianos EF, Pfeffer BJ, Damluji AA. Transcatheter Aortic Valve Replacement in a Sinus of Valsalva Aneurysm: The Evolving Role of Structural Cardiac Imaging. Circ Cardiovasc Imaging. 2019 Sep;12(9):e009386. doi: 10.1161/CIRCIMAGING.119.009386. Epub 2019 Aug 27. PMID: 31451007; PMCID: PMC7099850.

Salter ML, Liu X, Bae S, Chu NM, Miller Dunham A, Humbyrd C, Segev DL, McAdamsDeMarco MA. Fractures and Subsequent Graft Loss and Mortality among Older Kidney Transplant Recipients. J Am Geriatr Soc. 2019 August;67(8):1680-1688. PubMed PMID: 31059126; PubMed Central PMCID: PMC6684377; DOI: 10.1111/jgs.15962.

Schoenborn NL, Xue QL, Pollack CE, Janssen EM, Bridges JFP, Wolff AC, Boyd CM. Demographic, health, and attitudinal factors predictive of cancer screening decisions in older adults. Prev Med Rep. 2019 Jan 16;13:244-248. doi: 10.1016/j.pmedr.2019.01.007. eCollection 2019 Mar.

Schoenborn NL, Crossnohere NL, Janssen EM, Pollack CE, Boyd CM, Wolff AC, Xue QL, Massare J, Blinka M, Bridges JFP. Examining Generalizability of Older Adults’ Preferences for Discussing Cessation of Screening Colonoscopies in Older Adults with Low Health Literacy. J Gen Intern Med. 2019 Nov;34(11):2512-2519. doi: 10.1007/s11606-019-05258-2. Epub 2019 Aug 26. PMID: 31452029; PMCID: PMC6848333.

Sheehan OC, Leff B, Ritchie CS. Frailty Tools are Not Yet Ready for Prime Time in High-Risk Identification. J Hosp Med 2019 July;14(7):450. PubMed PMID: 31251723; DOI: 10.12788/jhm.3215.

Shrestha P, Haugen CE, Chu NM, Shaffer A, Garonzik-Wang J, Norman SP, Walston JD, Segev DL, McAdams-DeMarco MA. Racial differences in inflammation and outcomes of aging among kidney transplant candidates. BMC Nephrol. 2019 May 17;20(1):176. doi: 10.1186/s12882-019-1360-8. PMID: 31101015; PMCID: PMC6524264.

Tan J, Bae S, Segal JB, Zhu J, Alexander GC, Segev DL, McAdams-DeMarco M. Warfarin use and the risk of stroke, bleeding, and mortality in older adults on dialysis with incident atrial fibrillation. Nephrology (Carlton). 2019 Feb;24(2):234-244. doi: 10.1111/nep.13207.

Varadaraj V, Lee MJ, Tian J, Ramulu PY, Bandeen-Roche K, Swenor BK. Near Vision Impairment and Frailty: Evidence of an Association. Am J Ophthalmol. 2019 Dec;208:234-241. doi: 10.1016/j.ajo.2019.08.009. Epub 2019 Aug 26. PMID: 31465753; PMCID: PMC6888870.

Walker KA, Walston J, Gottesman RF, Kucharska-Newton A, Palta P, Windham BG. Midlife Systemic Inflammation Is Associated With Frailty in Later Life: The ARIC Study. J Gerontol A Biol Sci Med Sci. 2019 Feb 15;74(3):343-349. doi: 10.1093/gerona/gly045.

Walston J, Bandeen-Roche K, Buta B, Bergman H, Gill TM, Morley JE, Fried LP, Robinson TN, Afilalo J, Newman AB, López-Otín C, De Cabo R, Theou O, Studenski S, Cohen HJ, Ferrucci L. Moving Frailty Toward Clinical Practice: NIA Intramural Frailty Science Symposium Summary. J Am Geriatr Soc. 2019 Aug;67(8):1559-1564. doi: 10.1111/jgs.15928. Epub 2019 May 2. PMID: 31045254; PMCID: PMC6830521.

Walston J, Bandeen-Roche K, Ferrucci L. Reply to From Frailty to Gerastenia. J Am Geriatr Soc. 2019 Oct;67(10):2210-2211. doi: 10.1111/jgs.16142. Epub 2019 Aug 23. PMID: 31441501.

Wanigatunga AA, Gill TM, Marsh AP, Hsu FC, Yaghjyan L, Woods AJ, Glynn NW, King AC, Newton RL Jr, Fielding RA, Pahor M, Manini TM; Lifestyles Intervention and Independence for Elders Study Investigators. Effect of Hospitalizations on Physical Activity Patterns in Mobility-Limited Older Adults. J Am Geriatr Soc. 2019 Feb;67(2):261-268. doi: 10.1111/jgs.15631. Epub 2018 Nov 19.

Warsame F, Haugen CE, Ying H, Garonzik-Wang JM, Desai NM, Hall RK, Kambhampati R, Crews DC, Purnell TS, Segev DL, McAdams-DeMarco MA. Limited health literacy and adverse outcomes among kidney transplant candidates. Am J Transplant. 2019 Feb;19(2):457-465. doi: 10.1111/ajt.14994. Epub 2018 Aug 16.

Xue QL, Buta B, Ma L, Ge M, Carlson M. Integrating Frailty and Cognitive Phenotypes: Why, How, Now What? Curr Geriatr Rep. 2019 Jun;8(2):97-106. Epub 2019 Apr 24. PMID: 31815092; PMCID: PMC6897328.

Xue QL, Tian J, Walston JD, Chaves PHM, Newman AB, Bandeen-Roche K. Discrepancy in Frailty Identification: Move Beyond Predictive Validity. J Gerontol A Biol Sci Med Sci. 2020 Jan 20;75(2):387-393. doi: 10.1093/gerona/glz052. PMID: 30789645; PMCID: PMC7176056.

2018

Abadir P, Hosseini S, Faghih M, Ansari A, Lay F, Smith B, Beselman A, Vuong D, Berger A, Tian J, Rini D, Keenahan K, Budman J, Inagami T, Fedarko N, Marti G, Harmon J, Walston J. Topical Reformulation of Valsartan for Treatment of Chronic Diabetic Wounds.  J Invest Dermatol. 2018 Feb;138(2):434-443. doi: 10.1016/j.jid.2017.09.030. Epub 2017 Oct 24.

Buta B, Leder D, Miller R, Schoenborn NL, Green AR, Varadhan R. The Use of Figurative Language to Describe Frailty in Older Adults. J Frailty Aging 2018;7(2):127-133.

Chung T, Tian Y, Walston J, Hoke A. Increased Single-Fiber Jitter Level Is Associated With Reduction in Motor Function With Aging. Am J Phys Med Rehabil. 2018 Aug;97(8):551-556. doi: 10.1097/PHM.0000000000000915.

Gresham G, Dy SM, Zipunnikov V, Browner IS, Studenski SA, Simonsick EM, Ferrucci L, Schrack JA. Fatigability and endurance performance in cancer survivors: Analyses from the Baltimore Longitudinal Study of Aging. Cancer. 2018 Mar 15;124(6):1279-1287. doi: 10.1002/cncr.31238.

Gresham G, Schrack J, Gresham LM, Shinde AM, Hendifar AE, Tuli R, Rimel BJ, Figlin R, Meinert CL, Piantadosi S. Wearable activity monitors in oncology trials: Current use of an emerging technology. Contemp Clin Trials. 2018 Jan;64:13-21. doi: 10.1016/j.cct.2017.11.002.

Hall RK, McAdams-DeMarco MA. Breaking the cycle of functional decline in older dialysis patients. Semin Dial. 2018 Sep;31(5):462-467. doi: 10.1111/sdi.12695.

Harris MJ, Wirtz D, Wu PH. Dissecting cellular mechanics: Implications for aging, cancer, and immunity. Semin Cell Dev Biol. 2018 Oct 30. pii: S1084-9521(18)30143-5. doi: 10.1016/j.semcdb.2018.10.008. [Epub ahead of print].

Konel JM, Warsame F, Ying H, Haugen CE, Mountford A, Chu NM, Crews DC, Desai NM, Garonzik-Wang JM, Walston JD, Norman SP, Segev DL, McAdams-DeMarco MA. Depressive symptoms, frailty, and adverse outcomes among kidney transplant recipients. Clin Transplant. 2018 Oct;32(10):e13391. doi: 10.1111/ctr.13391.

Martinez-Amezcua P, Matsushita K, Simonsick EM, Ferrucci L, Schrack JA. Fatigability and functional performance among older adults with low-normal ankle-brachial index: Cross-sectional findings from the Baltimore Longitudinal Study of Aging. Atherosclerosis. 2018 May;272:200-206. doi: 10.1016/j.atherosclerosis.2018.03.037.

McAdams-DeMarco MA, Konel J, Warsame F, Ying H, González Fernández M, Carlson MC, Fine DM, Appel LJ, Segev DL. Intradialytic Cognitive and Exercise Training May Preserve Cognitive Function. Kidney Int Rep. 2017 Aug 19;3(1):81-88. doi: 10.1016/j.ekir.2017.08.006.

McAdams-DeMarco MA, Olorundare IO, Ying H, Warsame F, Haugen CE, Hall R, Garonzik-Wang JM, Desai NM, Walston JD, Norman SP, Segev DL. Frailty and Post-Kidney Transplant Health-Related Quality Of Life. Transplantation. 2018 Feb;102(2):291-299. doi: 10.1097/TP.0000000000001943. PMC5790611.

McAdams-DeMarco MA, Ying H, Thomas AG, Warsame F, Shaffer AA, Haugen CE, Garonzik-Wang JM, Desai NM, Varadhan R, Walston J, Norman SP, Segev DL. Frailty, Inflammatory Markers, and Waitlist Mortality Among Patients With End-stage Renal Disease in a Prospective Cohort Study. Transplantation. 2018 Oct;102(10):1740-1746. doi: 10.1097/TP.0000000000002213.

Nastasi AJ, Bryant TS, Le JT, Schrack J, Ying H, Haugen CE, González Fernández M, Segev DL, McAdams-DeMarco MA. Pre-kidney transplant lower extremity impairment and transplant length of stay: a time-to-discharge analysis of a prospective cohort study. BMC Geriatr. 2018 Oct 19;18(1):246. doi: 10.1186/s12877-018-0940-y.

Nastasi AJ, Ahuja A, Zipunnikov V, Simonsick EM, Ferrucci L, Schrack JA. Objectively Measured Physical Activity and Falls in Well-Functioning Older Adults: Findings From the Baltimore Longitudinal Study of Aging. Am J Phys Med Rehabil. 2018 April;97(4):255-260. PMID: 28915202; PMCID: PMC5851797; DOI: 10.1097/PHM.0000000000000830.

Schoenborn NL, Janssen EM, Boyd C, Bridges JFP, Wolff AC, Xue QL, Pollack CE. Older Adults’ Preferences for Discussing Long-Term Life Expectancy: Results From a National Survey. Ann Fam Med. 2018 Nov;16(6):530-537. doi: 10.1370/afm.230

Schoenborn NL, Van Pilsum Rasmussen SE, Xue QL, Walston JD, McAdams-Demarco MA, Segev DL, Boyd CM. Older adults’ perceptions and informational needs regarding frailty. BMC Geriatr. 2018 Feb 13;18(1):46. doi: 10.1186/s12877-018-0741-3. PMC5809948.

Schrack JA, Leroux A, Fleg JL, Zipunnikov V, Simonsick EM, Studenski SA, Crainiceanu C, Ferrucci L. Using Heart Rate and Accelerometry to Define Quantity and Intensity of Physical Activity in Older Adults. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):668-675. doi: 10.1093/gerona/gly029.

Segal JB, Varadhan R, Carlson MC, Walston JD. Claims-Based Frailty Index Options. J Gerontol A Biol Sci Med Sci. 2018 Apr 25. doi: 10.1093/gerona/gly055. [Epub ahead of print].

Semba RD, Gonzalez-Freire M, Moaddel R, Sun K, Fabbri E, Zhang P, Carlson OD, Khadeer M, Chia CW, Salem N Jr, Ferrucci L. Altered Plasma Amino Acids and Lipids Associated With Abnormal Glucose Metabolism and Insulin Resistance in Older Adults. J Clin Endocrinol Metab. 2018 Sep 1;103(9):3331-3339. doi: 10.1210/jc.2018-00480.

Shiroma EJ, Schrack JA, Harris TB. Accelerating Accelerometer Research in Aging. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):619-621. doi: 10.1093/gerona/gly033.

Simonsick EM, Aronson B, Schrack JA, Hicks GE, Jerome GJ, Patel KV, Studenski SA, Ferrucci L. Lumbopelvic Pain and Threats to Walking Ability in Well-Functioning Older Adults: Findings from the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc. 2018 Apr;66(4):714-720. doi: 10.1111/jgs.15280.

Simonsick EM, Schrack JA, Santanasto AJ, Studenski SA, Ferrucci L, Glynn NW. Pittsburgh Fatigability Scale: One-Page Predictor of Mobility Decline in Mobility-Intact Older Adults. J Am Geriatr Soc. 2018 Nov;66(11):2092-2096. doi: 10.1111/jgs.15531.

Skarupski KA, Gross A, Schrack JA, Deal JA, Eber GB. The Health of America’s Aging Prison Population. Epidemiol Rev. 2018 Jun 1;40(1):157-165. doi: 10.1093/epirev/mxx020.

Van Pilsum Rasmussen S, Konel J, Warsame F, Ying H, Buta B, Haugen C, King E, DiBrito S, Varadhan R, Rodríguez-Mañas L, Walston JD, Segev DL, McAdams-DeMarco MA. Engaging clinicians and patients to assess and improve frailty measurement in adults with end stage renal disease. BMC Nephrol. 2018 Jan 12;19(1):8. doi: 10.1186/s12882-017-0806-0.   PMC5766981.

Varadhan R, Walston JD, Bandeen-Roche K. Can a Link Be Found Between Physical Resilience and Frailty in Older Adults by Studying Dynamical Systems? J Am Geriatr Soc. 2018 Aug;66(8):1455-1458. doi: 10.1111/jgs.15409.

Walston J, Buta B, Xue QL. Frailty Screening and Interventions: Considerations for Clinical Practice. Clinics in Geriatric Medicine, 2018 Feb;34(1):25-38. doi: 10.1016/j.cger.2017.09.004. PMC5726589.

Wanigatunga AA, Gresham GK, Kuo PL, Martinez-Amezcua P, Zipunnikov V, Dy SM, Simonsick EM, Ferrucci L, Schrack JA. Contrasting characteristics of daily physical activity in older adults by cancer history. Cancer. 2018 Dec 15;124(24):4692-4699. doi: 10.1002/cncr.31745.

Wanigatunga AA, Manini TM, Cook DR, Katula J, Fielding RA, Kramer AF, Verghese J, Rapp SR, Sink KM, King AC, Buford TW, Anton S, Nadkarni N, Jennings JM, Reid K, Espeland MA, Gill TM, Pahor M, Nocera JR. Community-Based Activity and Sedentary Patterns Are Associated With Cognitive Performance in Mobility-Limited Older Adults. Front Aging Neurosci. 2018 Nov 15;10:341. doi: 10.3389/fnagi.2018.00341. eCollection 2018.

Wanigatunga AA, Simonsick EM, Zipunnikov V, Spira AP, Studenski S, Ferrucci L, Schrack JA. Perceived Fatigability and Objective Physical Activity in Mid- to Late-Life. J Gerontol A Biol Sci Med Sci. 2018 Apr 17;73(5):630-635. doi: 10.1093/gerona/glx181.

Wanigatunga AA, Varadhan R, Simonsick EM, Carlson OD, Studenski S, Ferrucci L, Schrack JA. Longitudinal Relationship between Interleukin-6 and Perceived Fatigability among well-functioning Adults in mid-to-late Life. J Gerontol A Biol Sci Med Sci. 2018 May 26. doi: 10.1093/gerona/gly120. 

Warsame F, Ying H, Haugen CE, Thomas AG, Crews DC, Shafi T, Jaar B, Chu NM, Segev DL, McAdams-DeMarco MA. Intradialytic Activities and Health-Related Quality of Life Among Hemodialysis Patients. Am J Nephrol. 2018;48(3):181-189. doi: 10.1159/000492623.

Wilson KL. Nuclear import pathway key to rescuing dominant progerin phenotypes. Sci Signal. 2018 Jul 3;11(537). pii: eaat9448. doi: 10.1126/scisignal.aat9448. Review.

Xue QL, Buta BJ, Varadhan R, Szanton SL, Chaves PH, Walston JD, Bandeen-Roche K. Chapter 9, Frailty and Geriatric Syndromes. In: Aging, Place, and Health: A Global Perspective. Satariano WA, Maus M, editors. Burlington, Massachusetts: Jones & Bartlett Learning; 2018; 191-230.

Yasar S, Varma VR, Harris GC, Carlson MC. Associations of Angiotensin Converting Enzyme-1 and Angiotensin II Blood Levels and Cognitive Function. J Alzheimers Dis. 2018;63(2):655-664. doi: 10.3233/JAD-170944.

2017

Abadir P, Jain A, Powell L, Xue QL, Tian J, Hamilton RG, Bennett D, Finucane T, Walston JD, Fedarko NS. Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes. Circulation. 2017 Jan 31;135(5):449-459. doi: 10.1161/CIRCULATIONAHA.116.022385. Epub 2016 Nov 30. PMC5285272. 

Abadir P, Ko F, Marx R, Powell L, Kieserman E, Yang H, Walston J. Co-Localization of Macrophage Inhibitory Factor and Nix in Skeletal Muscle of the Aged Male Interleukin 10 Null Mouse. J Frailty Aging. 2017;6(3):118-121. doi: 10.14283/jfa.2017.18. NIHMS ID: NIHMS911663.

Ashar FN, Zhang Y, Longchamps RJ, Lane J, Moes A, Grove ML, Mychaleckyj JC, Taylor KD, Coresh J, Rotter J, Bowerwinkle E, Pankratz N, Guallar E, Arking DE. Association of Mitochondrial DNA Copy Number with Cardiovascular Disease. JAMA Cardiol. 2017 Nov 1;2(11):1247-1255. doi: 10.1001/jamacardio.2017.3683.

Bandeen-Roche K, Espinoza SE. Getting Underneath Observed Frailty Transitions: Meaningful Change, Prevention, and Intervention. J Am Geriatr Soc. 2017 Sep 5. doi: 10.1111/jgs.15034. [Epub ahead of print]. PMID: 28873221. PMC Journal – In Process.

Buta B, Choudhury PP, Xue QL, Chaves P, Bandeen-Roche K, Shardell M, Semba RD, Walston J, Michos ED, Appel L, McAdams DeMarco M, Gross A, Yasar S, Ferrucci L, Fried LP, Kalyani RR. The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases. J Am Geriatr Soc. 2017 Mar;65(3):619-624. doi: 10.1111/jgs.14677. Epub 2016 Dec 23.  PMC5357177.

Chung T, Park JS, Kim S, Montes N, Walston J, Höke A. Evidence for dying-back axonal degeneration in age-associated skeletal muscle decline. Muscle Nerve. 2017 Jun;55(6):894-901. doi: 10.1002/mus.25267. Epub 2017 Apr 1.

Engelman M, Seplaki CL, Varadhan R. A Quiescent Phase in Human Mortality? Exploring the Ages of Least Vulnerability. Demography. 2017 Apr 10. doi: 10.1007/s13524-017-0569-z. [Epub ahead of print]. PMID: 28397179.

Gould LJ, Abadir PM, White-Chu EF. Age, Frailty and Impaired Wound Healing. R.A. Rosenthal et al. (eds.), Principles and Practice of Geriatric Surgery, Springer International Publishing Switzerland 2017. DOI 10.1007/978-3-319-20317-1_27-1. Book Chapter.

Graham A, Brown CH 4th. Frailty, Aging, and Cardiovascular Surgery. Anesth Analg. 2017 Apr;124(4):1053-1060. doi: 10.1213/ANE.0000000000001560.

Huisingh-Scheetz M, Walston J. How should older adults with cancer be evaluated for frailty? J Geriatr Oncol. 2017 Jan;8(1):8-15. doi: 10.1016/j.jgo.2016.06.003. Epub 2016 Jun 16. Review. PMC5161734. 

Kucharska-Newton AM, Palta P, Burgard S, Griswold ME, Lund JL, Capistrant BD, Kritchevsky SB, Bandeen-Roche K, Windham BG. Operationalizing Frailty in the Atherosclerosis Risk in Communities Study Cohort. Gerontol A Biol Sci Med Sci, 2017, Vol. 72, No. 3, 382–388. doi:10.1093/gerona/glw144. PMC Journal – In Process

Mauthner O, Claes V, Walston J, Engberg S, Binet I, Dickenmann M, Golshayan D, Hadaya K, Huynh-Do U, Calciolari S, De Geest S; GERAS study consortium; For the Psychosocial Interest Group; Swiss Transplant Cohort Study (STCS). ExplorinG frailty and mild cognitive impairmEnt in kidney tRansplantation to predict biomedicAl, psychosocial and health cost outcomeS (GERAS): protocol of a nationwide prospective cohort study. J Adv Nurs. 2017 Mar;73(3):716-734. doi: 10.1111/jan.13179. Epub 2016 Nov 23.

McAdams-DeMarco MA, Bae S, Chu N, Gross AL, Brown CH 4th, Oh E, Rosenberg P, Neufeld KJ, Varadhan R, Albert M, Walston J, Segev DL. Dementia and Alzheimer’s Disease among Older Kidney Transplant Recipients. J Am Soc Nephrol. 2017 May;28(5):1575-1583. doi: 10.1681/ASN.2016080816. Epub 2016 Dec 15. PMC5407731.

Phillip JM, Wu PS, Gilkes DM, Williams W, McGovern S, Daya J, Chen J, Aifuwa I, Lee JSH, Walston J, Wirtz D. Biophysical and Biomolecular Determination of Cellular Age in Humans. Nature Biomedical Engineering 2017 Jul 11; 1:0093.  doi:10.1038/s41551-017-0093.

Piggott DA, Muzaale AD, Varadhan R, Mehta SH, Westergaard RP, Brown TT, Patel KV, Walston JD, Leng SX, Kirk GD. Frailty and Cause-Specific Hospitalization Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):389-394. doi: 10.1093/gerona/glw142. PMID: 27516622.

Quartuccio M, Buta B, Kalyani RR. Comparative Effectiveness for Glycemic Control in Older Adults with Diabetes. Curr Geriatr Rep. 2017 Sep;6(3):175-186. doi: 10.1007/s13670-017-0215-z. Epub 2017 Jul 28. PMCID: PMC5585298.

Rodríguez-Mañas L, Walston JD. Frailty, what are we talking about? Implications for the daily clinical practice. Rev Esp Geriatr Gerontol. 2017 Jul – Aug;52(4):179-181. doi: 10.1016/j.regg.2017.04.004. Epub 2017 Jun 7. PMID: 28595963. NIHMS912015.

Segal JB, Chang HY, Du Y, Walston JD, Carlson MC, Varadhan R. Development of a Claims-based Frailty Indicator Anchored to a Well-established Frailty Phenotype. Med Care. 2017 May 16.  doi: 10.1097/MLR.0000000000000729. [Epub ahead of print]. 

Segal JB, Huang J, Roth DL, Varadhan R. External validation of the claims-based frailty index in the national health and aging trends study cohort. Am J Epidemiol. 2017 Sep 15;186(6):745-747. doi: 10.1093/aje/kwx257. PMC Journal – In Process.

Walston J. Frailty Research Moves Beyond Risk Assessment. J Gerontol A Biol Sci Med Sci, 2017, Vol. 72, No. 7, 915–916. doi:10.1093/gerona/glx085.

Walston J, Thomas N. Robinson TN, Zieman S, McFarland F, Carpenter CR, Althoff KN, Andrew MK, Blaum CS, Brown PJ, Buta B, Ely EW, Ferrucci L, High KP, Kritchevsky SB, Rockwood K, Schmader KE, Sierra F, Sink KM, Varadhan R, Hurria A. Integrating Frailty Research into the Medical Specialties—Report from a U13 Conference. J Am Geriatr Soc.  First published: 19 April 2017.

Westbrook R, Yang H, Langdon JM, Roy CN, Kim JA, Choudhury PP, Xue QL, diFrancesco A, de Cabo R, Walston JD. Aged Interleukin-10tm1Cgn chronically inflammed mice have substantially reduced fat mass, metabolic rate, and adipokines. PLoS One 2017 Dec 21;12(12):e0186811. doi: 10.1371/journal.pone.0186811. eCollection 2017. PMC5739384. 

Wyrobek J, LaFlam A, Max L, Tian J, Neufeld KJ, Kebaish KM, Walston JD, Hogue CW, Riley LH, Everett AD, Brown CH 4th. Association of intraoperative changes in brain-derived neurotrophic factor and postoperative delirium in older adults. Br J Anaesth. 2017 Aug 1;119(2):324-332. doi: 10.1093/bja/aex103. PMC Journal – In Process.

2016

Bakulski KM, Feinberg JI, Andrews SV, Yang J, Brown S, L McKenney S, Witter F, Walston J, Feinberg AP, Fallin MD. DNA methylation of cord blood cell types: Applications for mixed cell birth studies. Epigenetics. 2016 May 3;11(5):354-62. doi: 10.1080/15592294.2016.1161875. Epub 2016 Mar 28. PMC4889293

Brown CH, LaFlam A, Max L, Lymar D, Neufeld K, Tian J, Shah A, Whitman G, Hogue C. The impact of delirium after cardiac surgery on postoperative resource utilization. Ann Thorac Surg. 2016 May; 101(5): 1663–1669. PMCID: PMC5406132

Brown CH 4th, LaFlam A, Max L, Wyrobek J, Neufeld KJ, Kebaish KM, Cohen DB, Walston JD, Hogue CW, Riley LH. Delirium After Spine Surgery in Older Adults: Incidence, Risk Factors, and Outcomes. J Am Geriatr Soc. 2016 Oct;64(10):2101-2108. doi: 10.1111/jgs.14434. Epub 2016 Oct 3. PMCID: PMC5407286

Brown CH 4th, Max L, LaFlam A, Kirk L, Gross A, Arora R, Neufeld K, Hogue CW, Walston J, Pustavoitau A. The Association Between Preoperative Frailty and Postoperative Delirium After Cardiac Surgery. Anesth Analg. 2016 Apr 19. [Epub ahead of print] PMID: 27096563. PMCID: PMC5406128.

Buta B, Walston JD, Godino JG, Park M, Kalyani RR, Xue QL, Bandeen-Roche K, Varadhan R. Frailty Assessment Instruments: Systematic Characterization of the Uses and Contexts of Highly-Cited Instruments. Ageing Res Rev. 2016 Mar;26:53-61. doi: 10.1016/j.arr.2015.12.003. Epub 2015 Dec 7.  PMCID: PMC4806795.

Chung T, Park JS, Kim S, Montes N, Walston J, Höke A. Evidence for dying-back axonal degeneration in age-associated skeletal muscle decline. Muscle Nerve. 2016 Jul 27. doi: 10.1002/mus.25267. [Epub ahead of print]. PMCID: PMC5489232.

Cohen HJ, Walston JD, Rao SV, Schrier SL, Artz A; Partnership for Anemia: Clinical and Translational Trials in the Elderly Consortium. Renal Toxicity Associated with Salsalate in Elderly Adults with Anemia. J Am Geriatr Soc. 2016 Apr;64(4):898-9. doi: 10.1111/jgs.14065. No abstract available. PMID: 27100595. PMCID: PMC4863444.

Cooper Z, Rogers SO Jr, Ngo L, Guess J, Schmitt E, Jones RN, Ayres DK, Walston JD, Gill TM, Gleason LJ, Inouye SK, Marcantonio ER. Comparison of Frailty Measures as Predictors of Outcomes After Orthopedic Surgery.  J Am Geriatr Soc. 2016 Nov 1. doi: 10.1111/jgs.14387. [Epub ahead of print]. PMCID: PMC5173406.

Gross AL, Xue QL, Bandeen-Roche K, Fried LP, Varadhan R, McAdams-DeMarco MA, Walston J, Carlson MC. Declines and Impairment in Executive Function Predict Onset of Physical Frailty. J Gerontol A Biol Sci. 2016 Dec;71(12):1624-1630. Epub 2016 Apr 15. PMCID: PMC5106857.  

Gruenewald TL, Tanner EK, Fried LP, Carlson MC, Xue QL, Parisi JM, Rebok GW, Yarnell LM, Seeman TE. The Baltimore Experience Corps Trial: Enhancing Generativity via Intergenerational Activity Engagement in Later Life. J Gerontol B Psychol Sci Soc Sci. 2016 Jul;71(4):661-70. doi: 10.1093/geronb/gbv005. Epub 2015 Feb 25. PMID: 25721053. PMCID: PMC4903034.

Ko F, Abadir P, Marx R, Westbrook R, Cooke C, Yang H, Walston J. Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse. Exp Gerontol. 2016 Jan;73:23-7. doi: 10.1016/j.exger.2015.11.010. Epub 2015 Nov 18.PMID: 26596403. PMCID: PMC4725733.

Matteini AM, Tanaka T, Karasik D, Atzmon G, Chou WC, Eicher JD, Johnson AD, Arnold AM, Callisaya ML, Davies G, Evans DS, Holtfreter B, Lohman K, Lunetta KL, Mangino M, Smith AV, Smith JA, Teumer A, Yu L, Arking DE, Buchman AS, Chibinik LB, De Jager PL, Evans DA, Faul JD, Garcia ME, Gillham-Nasenya I, Gudnason V, Hofman A, Hsu YH, Ittermann T, Lahousse L, Liewald DC, Liu Y, Lopez L, Rivadeneira F, Rotter JI, Siggeirsdottir K, Starr JM, Thomson R, Tranah GJ, Uitterlinden AG, Völker U, Völzke H, Weir DR, Yaffe K, Zhao W, Zhuang WV, Zmuda JM, Bennett DA, Cummings SR, Deary IJ, Ferrucci L, Harris TB, Kardia SL, Kocher T, Kritchevsky SB, Psaty BM, Seshadri S, Spector TD, Srikanth VK, Windham BG, Zillikens MC, Newman AB, Walston JD, Kiel DP, Murabito JM. GWAS analysis of handgrip and lower body strength in older adults in the CHARGE consortium. Aging Cell. 2016 Oct;15(5):792-800. doi: 10.1111/acel.12468. Epub 2016 Jun 21. PMCID: PMC5013019.

McAdams-DeMarco MA, King EA, Luo X, Haugen C, DiBrito S, Shaffer A, Kucirka LM, Desai NM, Dagher NN, Lonze BE, Montgomery RA, Walston J, Segev DL. Frailty, Length of Stay, and Mortality in Kidney Transplant Recipients: A National Registry and Prospective Cohort Study. Ann Surg. 2016 Sep 21. [Epub ahead of print] PMCID: PMC5360544.

McAdams-DeMarco MA, Ying H, Olorundare I, King EA, Haugen C, Buta B, Gross AL, Kalyani R, Desai NM, Dagher NN, Lonze BE, Montgomery RA, Bandeen-Roche K, Walston JD, Segev DL. Individual Frailty Components and Mortality In Kidney Transplant Recipients. Transplantation. 2016 Oct 25. [Epub ahead of print]. PMCID: PMC5405005.

Pustavoitau A, Barodka V, Sharpless NE, Torrice C, Nyhan D, Berkowitz DE, Shah AS, Bandeen Roche KJ, Walston JD. Role of senescence marker p16(INK4a) measured in peripheral blood T-lymphocytes in predicting length of hospital stay after coronary artery bypass surgery in older adults. Exp Gerontol. 2016 Feb;74:29-36. doi: 10.1016/j.exger.2015.12.003. Epub 2015 Dec 9. PMCID: PMC4718794.

Sun DQ, Huang J, Varadhan R, Agrawal Y. Race and fall risk: data from the National Health and Aging Trends Study (NHATS). Age Ageing. 2016 Jan;45(1):120-7. doi: 10.1093/ageing/afv173. PMCID: PMC4711659.  PMCID: PMC4711659.

Wang GC, Han C, Detrick B, Casolaro V, Levine DM, Fried LP, Walston JD. Herpesvirus Infections and Risk of Frailty and Mortality in Older Women: Women’s Health and Aging Studies. J Am Geriatr Soc. 2016;64:998-1005. doi: 10.1111/jgs.14090. [Epub ahead of print] PMID: 27131018. PMCID: PMC4882224.

Xue QL, Yang H, Li HF, Abadir PM, Burks TN, Koch LG, Britton SL, Carlson J, Chen L, Walston JD, Leng SX. Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats. Aging (Albany NY). 2016 Mar 19. Vol. 8, No. 3. [Epub ahead of print] PMID: 26997106. PMCID: PMC4925827.

Xue QL, Tian J, Fried LP, Varadhan R, Kalyani R, Walston JD, Bandeen-Roche K. Physical Frailty Assessment: Can Simplification Be Achieved without Loss of Syndrome Measurement Validity? Am J Epidemiol. 2016 Jun 1;183(11):1037-44. doi: 10.1093/aje/kwv272. Epub 2016 May 5. PMCID: PMC4887575.

2015

Abadir PM, Siragy HM. Angiotensin type 1 receptor mediates renal production and conversion of prostaglandins E2 to F2α in conscious diabetic rats. J Renin Angiotensin Aldosterone Syst. 2015 Dec;16(4):774-9. doi: 10.1177/1470320315592566. Epub 2015 Jul 20. PMCID: PMC4831567.

Ashar FN, Moes A, Moore AZ, Grove ML, Chaves PH, Coresh J, Newman AB, Mattieni AM, Bandeen-Roche K, Boerwinkle E, Walston JD, Arking DE. Associations of mitochondrial DNA levels with frailty and all-cause mortality. J Mol Med (Berl). 2015 Feb;93(2):177-86. PMID: 25471480. PMCID: PMC4319988.

Bandeen-Roche K, Seplaki CL, Huang J, Buta B, Kalyani RR, Varadhan R, Xue QL, Walston JD, Kasper JD. Frailty in Older Adults: A Nationally Representative Profile in the United States. J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1427-34. doi: 10.1093/gerona/glv133. Epub 2015 Aug 21. PMCID: PMC4723664.

Bigelow RT, Semenov YR, Trevino C, Ferrucci L, Resnick SM, Simonsick EM, Xue QL, Agrawal Y. Association Between Visuospatial Ability and Vestibular Function in the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc. 2015 Sep;63(9):1837-44. doi: 10.1111/jgs.13609. Epub 2015 Aug 27. PMID: 26311169. PMCID: PMC4883683.

Burks TN, Marx R, Powell L, Rucker J, Bedja D, Heacock E, Smith BJ, Foster DB, Kass D, O’Rourke B, Walston JD, Abadir PM. Combined effects of aging and inflammation on renin-angiotensin system mediate mitochondrial dysfunction and phenotypic changes in cardiomyopathies. Oncotarget. 2015 May 20;6(14):11979-93. PMCID: PMC4494917.

Carlson MC, Kuo JH, Chuang YF, Varma V, Harris G, Albert M, Erickson KI, Kramer AF, Parisi JM, Xue QL, Tan E, Tanner EK, Gross A, Seeman TE, Gruenewald T, McGill S, Rebok GW, Fried LP. Impact of the Baltimore Experience Corps Trial on cortical and hippocampal volumes. Alzheimers Dement. 2015 Nov;11(11):1340-8. doi: 10.1016/j.jalz.2014.12.005. Epub 2015 Mar 31. PMID: 25835516. PMCID: PMC5179033.

Chen DS, Betz J, Yaffe K, Ayonayon HN, Kritchevsky S, Martin KR, Harris TB, Purchase-Helzner E, Satterfield S, Xue QL, Pratt S, Simonsick EM, Lin FR; for the Health ABC study. Association of Hearing Impairment with Declines in Physical Functioning and the Risk of Disability in Older Adults. J Gerontol A Biol Sci Med Sci. 2015 May;70(5):654-61. doi: 10.1093/gerona/glu207. Epub 2014 Dec 3. PMID: 25477427. PMCID: PMC4400396.

Dobrosielski DA, Patil S, Schwartz AR, Bandeen-Roche K, Stewart KJ. Effects of Exercise and Weight Loss in Older Adults with Obstructive Sleep Apnea.  Med Sci Sports Excerc. 2014 May 27. [Epub ahead of print] PMID: 24870569. PMCID: PMC4246024.

Faghih M, Hosseini SM, Smith B, Ansari AM, Lay F, Ahmed AK, Inagami T, Marti GP, Harmon JW, Walston JD, Abadir PM. Knockout of Angiotensin AT2 receptors accelerates healing but impairs quality. Aging (Albany NY). 2015 Dec;7(12):1185-97. PMCID: PMC4712341.

Genther DJ, Betz J, Pratt S, Ayonayon H, Kritchevsky S, Martin KR, Harris T, Helzner E, Satterfield S, Xue QL, Yaffe K, Simonsick EM, Lin FR. Association of hearing impairment and mortality in older adults. J Gerontol A Biol Sci Med Sci. 2015 Jan;70(1):85-90. doi: 10.1093/gerona/glu094. Epub 2014 Jul 14. PMID: 25024235. PMCID: PMC4296166.

Gould L, Abadir P, Brem H, Carter M, Conner-Kerr T, Davidson J, DiPietro L, Falanga V, Fife C, Gardner S, Grice E, Harmon J, Hazzard WR, High KP, Houghton P, Jacobson N, Kirsner RS, Kovacs EJ, Margolis D, McFarland Horne F, Reed MJ, Sullivan DH, Thom S, Tomic-Canic M, Walston J, Whitney JA, Williams J, Zieman S, Schmader K. Chronic wound repair and healing in older adults: current status and future research. J Am Geriatr Soc. 2015 Mar;63(3):427-38. doi: 10.1111/jgs.13332. Epub 2015 Mar 6. PMCID: PMC4582412.

Gould L, Abadir P, Brem H, Carter M, Conner-Kerr T, Davidson J, DiPietro L, Falanga V, Fife C, Gardner S, Grice E, Harmon J, Hazzard WR, High KP, Houghton P, Jacobson N, Kirsner RS, Kovacs EJ, Margolis D, McFarland Horne F, Reed MJ, Sullivan DH, Thom S, Tomic-Canic M, Walston J, Whitney J, Williams J, Zieman S, Schmader K. Chronic wound repair and healing in older adults: current status and future research. Wound Repair Regen. 2015 Jan-Feb;23(1):1-13. doi: 10.1111/wrr.12245. Epub 2015 Feb 13. PMID: 25486905. PMCID: PMC4414710.

Kalyani RR, Metter EJ, Egan J, Golden SH, Ferrucci L. Hyperglycemia predicts persistently lower muscle strength with aging. Diabetes Care. 2015 Jan;38(1):82-90. doi: 10.2337/dc14-1166. Epub 2014 Nov 12. PMCID: PMC4274779.

Ko F, Abadir P, Marx R, Westbrook R, Cooke C, Yang H, Walston J. Impaired mitochondrial degradation by autophagy in the skeletal muscle of the aged female interleukin 10 null mouse. Exp Gerontol. 2015 Nov 17. pii: S0531-5565(15)30088-7. doi: 10.1016/j.exger.2015.11.010. [Epub ahead of print] PMID: 26596403. PMCID: PMC4725733.

Langdon JM, Barkataki S, Berger AE, Cheadle C, Xue QL, Sung V, Roy CN. RAP-011, an activin receptor ligand trap, increases hemoglobin concentration in hepcidin transgenic mice. Am J Hematol. 2015 Jan;90(1):8-14. doi: 10.1002/ajh.23856. Epub 2014 Oct 25. PMID: 25236856. PMCID: PMC4276439.

Lee KT, Abadir PM. Failure of Glucose Monitoring in an Individual with Pseudohypoglycemia. J Am Geriatr Soc. 2015 Aug;63(8):1706-8. doi: 10.1111/jgs.13572. PMCID: PMC5407681.

Lin R, Zhang P, Cheetham AG, Walston J, Abadir P, Cui H. Dual Peptide Conjugation Strategy for Improved Cellular Uptake and Mitochondria Targeting. Bioconjug Chem 2015 Jan 21;26(1):71-7. doi: 10.1021/bc500408p. Epub 2014 Dec 30. PMCID: PMC4306504.

McAdams-DeMarco MA, Tan J, Salter ML, Gross A, Meoni LA, Jaar BG, Kao WL, Parekh RS, Segev DL, Sozio SM. Frailty and Cognitive Function in Incident Hemodialysis Patients. Clin J Am Soc Nephrol. 2015 Nov 16. pii: CJN.01960215. [Epub ahead of print] PMID: 26573615. PMCID: PMC4670760.

McAdams-DeMarco MA, Isaacs K, Darko L, Salter ML, Gupta N, King EA, Walston J, Segev DL. Changes in Frailty After Kidney Transplantation. J Am Geriatr Soc. 2015 Oct;63(10):2152-7. doi: 10.1111/jgs.13657. Epub 2015 Sep 29. PMID: 26416770. PMCID: PMC461802.

McAdams-DeMarco MA, Law A, King E, Orandi B, Salter M, Gupta N, Chow E, Alachkar N, Desai N,Varadhan R, Walston J, Segev DL. Frailty and mortality in kidney transplant recipients. Am J Transplant. 2015 Jan;15(1):149-54. doi: 10.1111/ajt.12992. Epub 2014 Oct 30. PMCID: PMC4332809.

McAdams-DeMarco MA, Law A, Tan J, Delp C, King EA, Orandi B, Salter M, Alachkar N, Desai N, Grams M, Walston J, Segev DL. Frailty, Mycophenolate Reduction, and Graft Loss in Kidney Transplant Recipients. Transplantation. 2015 Apr;99(4):805-10. PMCID: PMC4382409.

Palta P, Xue QL, Deal J, Fried LP, Carlson MC. Interleukin-6 and C-reactive protein levels and 9-year cognitive decline in community-dwelling older women: Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2015 Jul;70(7):873-8. doi: 10.1093/gerona/glu132. Epub 2014 Aug 26. PMID: 25161214. PMCID: PMC4481686.

Palta P, Szanton SL, Semba RD, Thorpe RJ, Varadhan R, Fried LP. Financial strain is associated with increased oxidative stress levels: The Women’s Health and Aging Studies. Geriatr Nurs. 2015 Mar-Apr;36(2 Suppl):S33-7. doi: 10.1016/j.gerinurse.2015.02.020. Epub 2015 Mar 14. PMID: 25784083. Available: http://www.sciencedirect.com/science/article/pii/S0197457215000695

Parisi JM, Kuo J, Rebok GW, Xue QL, Fried LP, Gruenewald TL, Huang J, Seeman TE, Roth DL, Tanner EK, Carlson MC. Increases in lifestyle activities as a result of Experience Corps® participation. J Urban Health. 2015 Feb;92(1):55-66. doi: 10.1007/s11524-014-9918-z. PMID: 25378282. PMCID: PMC4338117.

Parisi JM, Ramsey CM, Carlson MC, Xue, QL, Huang J, Romani WA, McGill S, Seeman TE, Tanner EK, Barron J, Tan E, Gruenewald TL, Diibor I, Fried LP, Rebok GW. Impact of Experience Corps® participation on school climate. Prev Sci. 2015 Jul;16(5):744-53. doi: 10.1007/s11121-015-0550-2. PMID: 25708453. PMCID: PMC4456199.

Phillip JM, Aifuwa, Walston JD, Wirtz D. The Mechanobiology of Aging. Annu Rev Biomed Eng. 2015 Dec 7;17:113-41. doi: 10.1146/annurev-bioeng-071114-040829. PMCID: PMC4886230.

Piggott DA, Varadhan R, Mehta SH, Brown TT, Li H, Walston JD, Leng SX, Kirk GD. Frailty, Inflammation, and Mortality Among Persons Aging With HIV Infection and Injection Drug Use. J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1542-7. doi: 10.1093/gerona/glv107. Epub 2015 Sep 18. PMCID: PMC4643614.

Robinson TN, Walston JD, Brummel NE, Deiner S, Brown CH 4th, Kennedy M, Hurria A. Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists. J Am Coll Surg. 2015 Dec;221(6):1083-92. doi: 10.1016/j.jamcollsurg.2015.08.428. Epub 2015 Sep 11. Review. PMID: 26422746. PMCID: PMC4673051.

Salter ML, Gupta N, Massie AB, McAdams-DeMarco MA, Law AH, Jacob RL, Gimenez LF, Jaar BG, Walston JD, Segev DL. Perceived frailty and measured frailty among adults undergoing hemodialysis: a cross-sectional analysis. BMC Geriatr. 2015 Apr 24;15:52. doi: 10.1186/s12877-015-0051-y.  PMID: 25903561. PMCID: PMC4428253.

Semenov YR, Bigelow RT, Xue QL, Lac Sd, Agrawal Y. Association Between Vestibular and Cognitive Function in U.S. Adults: Data From the National Health and Nutrition Examination Survey. J Gerontol A Biol Sci Med Sci. 2016 Feb;71(2):243-50. doi: 10.1093/gerona/glv069. Epub 2015 Jul 28. PMID: 26219850. PMC Journal – In Process.

Theou O, Walston J, Rockwood K. Operationalizing Frailty Using the Frailty Phenotype and Deficit Accumulation Approaches. Interdiscip Top Gerontol Geriatr. 2015;41:66-73. doi: 10.1159/000381164. Epub 2015 Jul 17. PMID: 26301980. PMCID: PMC4886227

Vandiver AR, Irizarry RA, Hansen KD, Garza LA, Runarsson A, Li X, Chien AL, Wang TS, Leung SG, Kang S, Feinberg AP. Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biol. 2015 Apr 16;16:80. doi: 10.1186/s13059-015-0644-y. PMCID: PMC4423110

Walston JD. Connecting Age-Related Biological Decline to Frailty and Late-Life Vulnerability. Nestle Nutr Inst Workshop Ser. 2015 Oct;83:1-10. doi: 10.1159/000382052. Epub 2015 Oct 20. PMID: 26485518. PMCID: PMC4871248.

Walston JD, Bandeen-Roche K. Frailty: a tale of two concepts. BMC Med. 2015 Aug 11;13:185. doi: 10.1186/s12916-015-0420-6.  PMID: 26265077. PMCID: PMC4531437. Xue QL, Guralnik JM, Beamer BA, Fried LP, Chaves PHM. Monitoring six-month trajectory of grip strength improves the prediction of long-term change in grip strength in disabled older women. J Gerontol A Biol Sci Med Sci. 2015 Mar;70(3):367-73. doi: 10.1093/gerona/glu149. Epub 2014 Aug 28.  PMID: 25167868. PMCID: PMC4400523.

2014

Agrawal Y, Schubert MC, Migliaccio AA, Zee DS, Schneider E, Lehnen N, Carey JP. Evaluation of quantitative head impulse testing using search coils versus video-oculography in older individuals. Otol Neurotol. 2014 Feb;35(2):283-8. doi: 10.1097/MAO.0b013e3182995227. PMID: 24080977. PMCID: PMC4532669.

Akki A, Yang H, Gupta A, Chacko VP, Yano T, Leppo MK, Steenbergen C, Walston J, Weiss RG. Skeletal muscle ATP kinetics are impaired in frail mice. Age (Dordr). 2014 Feb;36(1):21-30. doi: 10.1007/s11357-013-9540-0. Epub 2013 May 22. PMID: 23695949. PMCID: PMC3889887.

Artz AS, Xue QL, Wickrema A, Hesdorffer C, Ferrucci L, Langdon JM, Walston JD, Roy CN. Unexplained anaemia in the elderly is characterised by features of low grade inflammation. Br J Haematol. 2014 Oct;167(2):286-9. doi: 10.1111/bjh.12984. PMCID: PMC4188639.

Baxter M, Agrawal Y. Vestibular dysfunction in Turner syndrome: a case report. Otol Neurotol. 2014 Feb;35(2):294-6. doi: 10.1097/MAO.0b013e31829e16df. PMID: 24448289. NIHMSID911666.

Chuang YF, Eldreth D, Erickson KI, Varma V, Harris G, Fried LP, Rebok GW, Tanner EK, Carlson MC. Cardiovascular risks and brain function: a functional magnetic resonance imaging study of executive function in older adults. Neurobiol Aging. 2014 Jun;35(6):1396-403. doi: 10.1016/j.neurobiolaging.2013.12.008. Epub 2013 Dec 18. PMID: 24439485. PMCID: PMC4282177.

Cohen AA, Milot E, Li Q, Legault V, Fried LP, Ferrucci L. Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Exp Gerontol. 2014 Sep;57:203-10. doi: 10.1016/j.exger.2014.04.016. Epub 2014 May 5. PMID: 24802990. PMCID: PMC4428144.

Corriere MD, Minang LB, Sisson SD, Brancati FL, Kalyani RR. The use of clinical guidelines highlights ongoing educational gaps in physicians’ knowledge and decision making related to diabetes. BMC Med Educ. 2014 Sep 8;14:186. doi: 10.1186/1472-6920-14-186. PMID: 25199672. PMCID: PMC4162949.

Corriere MD, Yao W, Xue QL, Cappola AR, Fried LP, Thorpe RJ Jr, Szanton SL, Kalyani RR. The association of neighborhood characteristics with obesity and metabolic conditions in older women. J Nutr Health Aging. 2014 Nov;18(9):792-8. doi: 10.1007/s12603-014-0477-5. PMCID: PMC4414394.

Davalos-Bichara M, Agrawal Y. Normative results of healthy older adults on standard clinical vestibular tests. Otol Neurotol. 2014 Feb;35(2):297-300. doi: 10.1097/MAO.0b013e3182a09ca8. PMID: 24136315. PMCID: PMC4069156.

Jonassaint CR, Varma VR, Chuang YF, Harris GC, Yasar S, Polinder-Bos H, Carlson MC. Lower hemoglobin is associated with poorer cognitive performance and smaller brain volume in older adults. J Am Geriatr Soc. 2014 May;62(5):972-3. doi: 10.1111/jgs.12810. PMCID: PMC4292910.

Kalyani RR, Corriere M, Ferrucci L. Age-related and disease-related muscle loss: the effect of diabetes, obesity, and other diseases. Lancet Diabetes Endocrinol. 2014 Oct;2(10):819-29. doi: 10.1016/S2213-8587(14)70034-8. Epub 2014 Mar 6. PMID: 24731660. PMCID: PMC4156923.

Kalyani RR, Tra Y, Egan JM, Ferrucci L, Brancati F. Hyperglycemia is associated with relatively lower lean body mass in older adults. J Nutr Health Aging. 2014;18(8):737-43. doi: 10.1007/s12603-014-0445-0. PMID: 25286453. PMCID: PMC4414396.

Krall JR, Carlson MC, Fried LP, Xue QL. Examining the dynamic, bidirectional associations between cognitive and physical functions. Am J Epidemiol. 2014 Oct 15;180(8):838-46. doi: 10.1093/aje/kwu198. Epub 2014 Sep 8. PMID: 25205829. PMCID: PMC4188340.

Langdon JM, Yates SC, Femnou LK, McCranor GJ, Cheadle C, Xue QL, Vaulont S, Civin CI, Walston JD, Roy CN. Hepcidin-dependent and hepcidin-independent regulation of erythropoiesis in a mouse model of anemia of chronic inflammation. Am J Hematol. 2014 May;89(5):470-9. doi: 10.1002/ajh.23670. Epub 2014 Feb 24. PMID: 24415655. PMCID: PMC4200395.

Li HF, Weng P, Najarro K, Xue QL, Semba RD, Margolick JB, Leng SX. Chronic CMV infection in older women: Longitudinal comparisons of CMV DNA in peripheral monocytes, anti-CMV IgG titers, serum IL-6 levels, and CMV pp65 (NLV)-specific CD8+ T-cell frequencies with twelve year follow-up. Exp Gerontol. 2014 Jun;54:84-9. doi: 10.1016/j.exger.2014.01.010. Epub 2014 Jan 15. PMID: 24440388. PMCID: PMC3989432.

Lin CH, Yang H, Xue QL, Chuang YF, Roy CN, Abadir P, Walston JD. Losartan improves measures of activity, inflammation, and oxidative stress in older mice. Exp Gerontol. 2014 Oct;58:174-8. doi: 10.1016/j.exger.2014.07.017. Epub 2014 Jul 28. PMID: 25077714. PMCID: PMC4252828.

Matteini AM, Li J, Lange EM, Tanaka T, Lange LA, Tracy RP, Wang Y, Biggs ML, Arking DE, Fallin MD, Chakravarti A, Psaty BM, Bandinelli S, Ferrucci L, Reiner AP, Walston JD. Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults. Cytokine. 2014 Jan;65(1):10-6. doi: 10.1016/j.cyto.2013.10.002. Epub 2013 Oct 29.  PMID: 24182552. PMCID: PMC4060632.

McAdams-Demarco MA, Grams ME, King E, Desai NM, Segev DL. Sequelae of early hospital readmission after kidney transplantation. Am J Transplant. 2014 Feb;14(2):397-403. doi: 10.1111/ajt.12563. Epub 2014 Jan 21. PMID: 24447652. PMCID: PMC3998748.

Price E, Artz AS, Barnhart H, Sapp S, Chelune G, Ershler WB, Walston JD, Gordeuk VR, Berger NA, Reuben D, Prchal J, Rao SV, Roy CN, Supiano MA, Schrier SL, Cohen HJ. A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL. Blood Cells Mol Dis. 2014 Dec;53(4):221-30. doi: 10.1016/j.bcmd.2014.06.003. PMCID: PMC4198614

RoyChoudhury A, Dam TL, Varadhan R, Xue QL, Fried LP. Analyzing Feed-Forward Loop Relationship in Aging Phenotypes: Physical Activity and Physical Performance. Mech Ageing Dev. 2014 Nov-Dec;141-142:5-11. doi: 10.1016/j.mad.2014.08.001. Epub 2014 Aug 26. PMID: 25168630. PMCID: PMC4310806.

Salter ML, McAdams-Demarco MA, Law A, Kamil RJ, Meoni LA, Jaar BG, Sozio SM, Kao WH, Parekh RS, Segev DL. Age and sex disparities in discussions about kidney transplantation in adults undergoing dialysis. J Am Geriatric Soc. 2014 May;62(5):843-9. doi: 10.1111/jgs.12801. Epub 2014 May 6. PMID: 24801541. PMCID: PMC4024077

Schrack JA, Zipunnikov V, Goldsmith J, Bandeen-Roche K, Crainiceanu CM, Ferrucci L. Estimating energy expenditure from heart rate in older adults: a case for calibration. PLoS One. 2014 Apr 30;9(4):e93520. doi: 10.1371/journal.pone.0093520. eCollection 2014. PMID: 24787146. PMCID: PMC4005766.

Seplaki CL, Agree EM, Weiss CO, Szanton SL, Bandeen-Roche K, Fried LP. Assistive devices in context: cross-sectional association between challenges in the home environment and use of assistive devices for mobility. Gerontologist. 2014 Aug;54(4):651-60. doi: 10.1093/geront/gnt030. Epub 2013 Apr 24. PMID: 23616569. PMCID: PMC4110451.

Sun DQ, Zuniga MG, Davalos-Bichara M, Carey JP, Agrawal Y. Evaluation of a bedside test of utricular function – the bucket test – in older individuals. Acta Otolaryngol. 2014 Apr;134(4):382-9. doi: 10.3109/00016489.2013.867456. Epub 2014 Jan 27. PMID: 24460151. PMCID: PMC4285154

Tan EJ, McGill S, Tanner EK, Carlson MC, Rebok GW, Seeman TE, Fried LP. The evolution of an academic-community partnership in the design, implementation, and evaluation of Experience Corps® Baltimore City: a courtship model. Gerontologist. 2014 Apr;54(2):314-21. doi: 10.1093/geront/gnt072. Epub 2013 Jul 25. PMID: 23887931. PMCID: PMC3954416.

Vajapey R, Rini D, Walston J, Abadir P. The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance. Front Physiol. 2014 Nov 24;5:439. doi:10.3389/fphys.2014.00439. eCollection 2014. PMCID: PMC4241834.

Varadhan R, Yao W, Matteini A, Beamer BA, Xue QL, Yang H, Manwani B, Reiner A, Jenny N, Parekh N, Fallin MD, Newman A, Bandeen-Roche K, Tracy R, Ferrucci L, Walston J. Simple biologically informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults. J Gerontol A Biol Sci Med Sci. 2014 Feb;69(2):165-73. doi: 10.1093/gerona/glt023. Epub 2013 May 20. PMID: 23689826. PMCID: PMC4038244.

Varadhan R, Xue QL, Bandeen-Roche K. Semicompeting risks in aging research: methods, issues, and needs. Lifetime Data Anal. 2014 Oct;20(4):538-62. doi: 10.1007/s10985-014-9295-7. Epub 2014 Apr 12. PMID: 24729136. PMCID: PMC4430119.

Varma VR, Tan EJ, Wang T, Xue QL, Fried LP, Seplaki CL, King AC, Seeman TE, Rebok GW, Carlson MC. Low-intensity walking activity is associated with better health. J Appl Gerontol. 2014 Oct;33(7):870-87. doi: 10.1177/0733464813512896. Epub 2013 Dec 11. PMID: 24652915. PMCID: PMC4053519.

Varma VR, Carlson MC, Parisi JM, Tanner EK, McGill S, Fried LP, Song LH, Gruenewald TL. Experience Corps Baltimore: Exploring the Stressors and Rewards of High-intensity Civic Engagement. Gerontologist. 2014 Apr 10. [Epub ahead of print] PMID: 24589989. PMCID: PMC4668764.

Weinreich HM, Agrawal Y. The link between allergy and Menière’s disease. Curr Opin Otolaryngol Head Neck Surg. 2014 Jun;22(3):227-30. doi: 10.1097/MOO.0000000000000041. PMID: 24573125. PMCID: PMC4549154.

Weiss CO, Varadhan R, Puhan MA, Vickers A, Bandeen-Roche K, Boyd CM, Kent DM. Multimorbidity and evidence generation. J Gen Intern Med. 2014 Apr;29(4):653-60. doi: 10.1007/s11606-013-2660-5. Epub 2014 Jan 18. Review. PMID: 24442333. PMCID: PMC3965759. Xue QL, Varadhan R. What is missing in the validation of frailty instruments? J Am Med Dir Assoc. 2014 Feb;15(2):141-2. doi: 10.1016/j.jamda.2013.11.007. Epub 2014 Jan 7. PMID: 24405640. Available: http://www.sciencedirect.com/science/article/pii/S1525861013006403.

2013

Abraham S, Hall E, Golden SH, Kalyani RR. Foreign Body with Gas Gangrene in an Elderly Patient with Diabetes. J Diabetes Metab. 2013 Nov 1;4(9):310. PMCID: PMC4083857

Agrawal Y, Bremova T, Kremmyda O, Strupp M, MacNeilage PR. Clinical testing of otolith function: perceptual thresholds and myogenic potentials. J Assoc Res Otolaryngol. 2013 Dec;14(6):905-15. PMID: 2407767. PMCID: PMC3825026.

Agrawal Y, Bremova T, Kremmyda O, Strupp M. Semicircular canal, saccular and utricular function in patients with bilateral vestibulopathy: analysis based on etiology. J Neurol. 2013 Mar;260(3):876-83. doi: 10.1007/s00415-012-6724-y. Epub 2012 Oct 27. PMID: 23104126.

Agrawal Y, Ward BK, Minor LB. Vestibular dysfunction: prevalence, impact and need for targeted treatment. J Vestib Res. 2013;23(3):113-7. doi: 10.3233/VES-130498. Review. No abstract available. PMID: 24177344.

Bremova T, Bayer O, Agrawal Y, Kremmyda O, Brandt T, Teufel J, Strupp M. Ocular VEMPs indicate repositioning of otoconia to the utricle after successful liberatory maneuvers in benign paroxysmal positioning vertigo. Acta Otolaryngol. 2013 Dec;133(12):1297-303. doi: 10.3109/00016489.2013.829922. PMID: 24245699. PMCID: PMC4069124.

Cohen AA, Milot E, Yong J, Seplaki CL, Fülöp T, Bandeen-Roche K, Fried LP. A novel statistical approach shows evidence for multi-system physiological dysregulation during aging. Mech Ageing Dev. 2013 Mar;134(3-4):110-7. doi: 10.1016/j.mad.2013.01.004. Epub 2013 Jan 31.

Corriere M, Rooparinesingh N, Kalyani RR. Epidemiology of diabetes and diabetes complications in the elderly: an emerging public health burden. Curr Diab Rep. 2013 Dec;13(6):805-13. doi: 10.1007/s11892-013-0425-5. PMID: 24018732. PMCID: PMC3856245.

Davalos-Bichara M, Lin FR, Carey JP, Walston JD, Fairman JE, Schubert MC, Barron JS, Hughes J, Millar JL, Spar A, Weber KL, Ying HS, Zackowski KM, Zee DS, Agrawal Y. Development and validation of a falls-grading scale. J Geriatr Phys Ther. 2013 Apr-Jun;36(2):63-7. doi: 10.1519/JPT.0b013e31825f6777.  PMID: 22810170 [PubMed – indexed for MEDLINE] PMCID: PMC3867809.

Fried LP, Carlson MC, McGill S, Seeman T, Xue QL, Frick K, Tan E, Tanner EK, Barron J, Frangakis C, Piferi R, Martinez I, Gruenewald T, Martin BK, Berry-Vaughn L, Stewart J, Dickersin K, Willging PR, Rebok GW. Experience Corps: a dual trial to promote the health of older adults and children’s academic success. Contemp Clin Trials. 2013 Sep;36(1):1-13. doi: 10.1016/j.cct.2013.05.003. Epub 2013 May 13. PMID: 23680986. PMCID: PMC4112377.

Kalyani RR, Tra Y, Yeh HC, Egan JM, Ferrucci L, Brancati FL. Quadriceps strength, quadriceps power, and gait speed in older U.S. adults with diabetes mellitus: results from the National Health and Nutrition Examination Survey, 1999-2002. J Am Geriatr Soc. 2013 May;61(5):769-75. doi: 10.1111/jgs.12204. Epub 2013 Apr 25. PMID: 23617584.  PMCID: PMC3725774.

McAdams-Demarco MA, Suresh S, Law A, Salter ML, Gimenez LF, Jaar BG, Walston JD, Segev DL. Frailty and falls among adult patients undergoing chronic hemodialysis: a prospective cohort study. BMC Nephrol. 2013 Oct 16;14(1):224. [Epub ahead of print]  PMID: 24131569.  PMCID: PMC3852906.

McAdams-DeMarco MA, Law A, Salter ML, Boyarsky B, Gimenez L, Jaar BG, Walston JD, Segev DL. Frailty as a novel predictor of mortality and hospitalization in individuals of all ages undergoing hemodialysis. J Am Geriatr Soc. 2013 Jun;61(6):896-901. doi: 10.1111/jgs.12266. Epub 2013 May 27. PMID: 23711111. PMCID: PMC3938084. 

McAdams-MeMarco MA, Law A, Salter ML, Chow E, Grams M, Walston J, Segev DL. Frailty and early hospital readmission after kidney transplantation. Am J Transplant. 2013 Aug;13(8):2091-5. doi: 10.1111/ajt.12300. Epub 2013 June 3. PMID 23731461.

McCranor BJ, Langdon JM, Prince OD, Femnou LK, Berger AE, Cheadle C, Civin CI, Kim A, Rivera S, Ganz T, Vaulont S, Xue QL, Walston JD, Roy CN. Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age. Haematologica. 2013 Oct;98(10):1633-40. doi: 10.3324/haematol.2013.087114. Epub 2013 Aug 30. PMID: 23996485.  PMCID: PMC3789470.

Sikka G, Miller K, Jung S, Fraser III CD, Ellis C, Ross D, Vandegaer K, Bedja D, Gabrielson K, Walston JD, Berkowitz DE, Barouch LA. Interleukin 10 Knockout Frail Mice Develop Cardiac and Vascular Dysfunction with Increased Age. Exp Gerontol 2013 Feb;48(2):128-35. doi: 10.1016/j.exger.2012.11.001. Epub 2012 Nov 13. PMID: 23159957. PMCID: PMC3744178.

Varadhan R, Yao W, Matteini A, Beamer BA, Xue QL, Yang H, Manwani B, Reiner A, Jenny N, Parekh N, Fallin MD, Newman A, Bandeen-Roche K, Tracy R, Ferrucci L, Walston J. Simple Biologically Informed Inflammatory Index of Two Serum Cytokines Predicts 10 Year All-Cause Mortality in Older Adults. J Gerontol A Biol Sci Med Sci glt023 first published online May 20, 2013 doi:10.1093/gerona/glt023. PMID: 23689826.

Yasar S, Xia J, Yao W, Furberg CD, Xue QL, Mercado CI, Fitzpatrick AL, Fried LP, Kawas CH, Sink KM, Williamson JD,DeKosky ST, Carlson MC; Ginkgo Evaluation of Memory (GEM) Study Investigators. Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study. Neurology. 2013 Sep 3;81(10):896-903. doi: 10.1212/WNL.0b013e3182a35228. Epub 2013 Aug 2. PMCID: PMC3885216.

2012

Abadir PM, Walston JD, Carey RM. Subcellular characteristics of functional intracellular renin-angiotensin systems. Peptides. 2012 Dec;38(2):437-45. doi: 10.1016/j.peptides.2012.09.016. Epub 2012 Sep 29. PubMed PMID: 23032352. PMCID: PMC3770295.

Agrawal Y, Zuniga MG, Davalos-Bichara M, Schubert MC, Walston JD, Hughes J, Carey JP. Decline in semicircular canal and otolith function with age. Otol Neurotol. 2012 Jul;33(5):832-9. PMCID: PMC3376350.

Andres-Mateos E, Mejias R, Soleimani A, Lin BM, Burks TN, Marx R, Lin B, Zellars RC, Zhang Y, Huso DL, Marr TG, Leinwand LA, Merriman DK, Cohn RD. Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels. PLoS One. 2012;7(11):e48884. doi: 10.1371/journal.pone.0048884. Epub 2012 Nov 14. PMID: 23155423 [PubMed – in process] PMCID: PMC3498346.

Chang SS, Weiss CO, Xue QL, Fried LP. Association between inflammatory-related disease burden and frailty: results from the Women’s Health and Aging Studies (WHAS) I and II. Arch Gerontol Geriatr. 2012 Jan;54(1):9-15. Epub 2011 Jul 16. PMID: 21763008. PMCID: PMC3197795.

Garonzik-Wang JM, Govindan P, Grinnan JW, Liu M, Ali HM, Chakraborty A, Jain V, Ros RL, James NT, Kucirka LM, Hall EC, Berger JC, Montgomery RA, Desai NM, Dagher NN, Sonnenday CJ, Englesbe MJ, Makary MA, Walston JD, Segev DL. Frailty and delayed graft function in kidney transplant recipients. Arch Surg. 2012 Feb;147(2):190-3. PMID: 22351919.

Giovannetti ER, Wolff JL, Xue QL, Weiss CO, Leff B, Boult C, Hughes T, and Boyd CM. Difficulty with health care tasks among caregivers of multimorbid older adults. J Gen Intern Med. 2012 Jan;27(1):37-44. PMID: 21874385. PMCID: PMC3250537.

Kalyani RR, Tian J, Xue Q, Walston JW, Cappola AR, Fried LP, Brancati FL, Blaum CS. Hyperglycemia and Incidence of Frailty and Lower Extremity Mobility Limitations in Older Women. J Am Geriatr Soc. 2012 Aug 10. doi: 10.1111/j.1532-5415.2012.04099.x. [Epub ahead of print] PMID: 22882211.

Kalyani RR, Varadhan R, Weiss CO, Fried LP, Cappola A. Frailty Status and Altered Dynamics of Circulating Energy Metabolism Hormones After Oral Glucose in Older Women. The Journal of Nutrition, Health & Aging 2012 June 25, DOI: 10.1007/s12603-012-0066-4 [online first ahead of print].

Kalyani RR, Metter EJ, Ramachandran R, Chia CW, Saudek CD, Ferrucci L. Glucose and Insulin Measurements From the Oral Glucose Tolerance Test and Relationship to Muscle Mass. J Gerontol A Biol Sci Med Sci. 2012 Jan;67(1):74-81. Epub 2011 Feb 24. PMID: 21350243. PMCID: PMC3260481.

Ko F, Yu Q, Xue QL, Yao W, Brayton C, Yang H, Fedarko N, Walston J. Inflammation and mortality in a frail mouse model. Age (Dordr). 2012 Jun; 34(3):705-15. Epub 2011 June 2. PMID:21633802. PMCID: PMC3337927.

Lin FR, Ferrucci L. Hearing loss and falls among older adults in the United States. Arch Intern Med. 2012 Feb 27;172(4):369-71. PMID:22371929 [PubMed – in process] PMCID: PMC3518403.

McAdams-Demarco MA, Law A, Garonzik-Wang JM, Gimenez L, Jaar BG, Walston JD, Segev DL. Activity of daily living disability and dialysis mortality: better prediction using metrics of aging. J Am Geriatr Soc. 2012 Oct;60(10):1981-2. doi: 10.1111/j.1532-5415.2012.04161.x. PubMed PMID: 23057455.

Mielke MM, Bandaru VV, Haughey NJ, Xia J, Fried LP, Yasar S, Albert M, Varma V, Harris G, Schneider EB, Rabins PV, Bandeen-Roche K, Lyketsos CG, Carlson MC. Serum ceramides increase the risk of Alzheimer disease: the Women’s Health and Aging Study II. Neurology. 2012 Aug 14;79(7):633-41. doi: 10.1212/WNL.0b013e318264e380. Epub 2012 Jul 18. PMID: 22815558 [PubMed – indexed for MEDLINE] PMCID: PMC3414665.

Mielke MM, Okonkwo OC, Oishi K, Mori S, Tighe S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer’s disease. Alzheimers Dement. 2012;8(2):105-13. doi: 10.1016/j.jalz.2011.05.2416. PMID: 22404852 [PubMed – indexed for MEDLINE] PMCID: PMC3305232.

Petersen J, Bandeen-Roche K, Budtz-Jørgensen E, Larsen KG. Predicting Latent Class Scores for Subsequent Analysis. Psychometrika. 2012 Apr 1;77(2):244-262.

Prince OD, Langdon JM, Layman AJ, Prince IC, Sabogal M, Mak HH, Berger AE, Cheadle C, Chrest FJ, Yu Q, Andrews NC, Xue QL, Civin CI, Walston JD, Roy CN. Late stage erythroid precursor production is impaired in mice with chronic inflammation. Haematologica. 2012 Nov;97(11):1648-56. doi: 10.3324/haematol.2011.053397. Epub 2012 May 11. PMID: 22581006. PMCID: PMC3487436.

Roy CN, Semba RD, Sun K, Bandinelli S, Varadhan R, Patel KV, Guralnik JM, Ferrucci L. Circulating selenium and carboxymethyl-lysine, an advanced glycation endproduct, are independent predictors of anemia in older community-dwelling adults. Nutrition. 2012 Feb 9. [Epub ahead of print] PMID:22325035. PMCID: PMC3377823.

Talegawkar SA, Bandinelli S, Bandeen-Roche K, Chen P, Milaneschi Y, Tanaka T, Semba RD, Guralnik JM, Ferrucci L. A higher adherence to a Mediterranean-style diet is inversely associated with the development of frailty in community-dwelling elderly men and women. J Nutr. 2012 Dec;142(12):2161-6. doi: 10.3945/jn.112.165498. Epub 2012 Oct 24. PMID: 23096005. PMCID: PMC3497964.

Tighe SK, Oishi K, Mori S, Smith GS, Albert M, Lyketsos CG, Mielke MM. Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s dementia. J Neuropsychiatry Clin Neurosci. 2012 Fall;24(4):484-8. doi: 10.1176/appi.neuropsych.11120375. PMID: 23224456 [PubMed – in process] PMCID: PMC3533244.

Walston JD. Sarcopenia in older adults. Curr Opin Rheumatol. 2012 Nov;24(6):623-7. PubMed PMID: 22955023.

Wang GC, Dash P, McCullers JA, Doherty PC, Thomas PG. T Cell Receptor αβ Diversity Inversely Correlates with Pathogen-Specific Antibody Levels in Human Cytomegalovirus Infection. Sci Transl Med 4 April 2012: Vol. 4, Issue 128, p. 128ra42. DOI: 10.1126/scitranslmed.3003647. PMC Journal- In Process.

Xue QL, Bandeen-Roche K, Mielenz, TJ, Seplaki CL, Szanton SL, Thorpe RJ, Kalyani RR, Chaves PH, Dam TT, Ornstein K, RoyChoudhury A, Yao WL, Fried LP. Patterns of 12-Year Change in Physical Activity in Community-Dwelling Older Women: Can Modest Levels of Physical Activity Help Older Women Live Longer? Am J Epidemiol. 2012 Aug 30. [Epub ahead of print] PMID: 22935515.

Zhang T, Hwang HY, Hao H, Talbot C Jr, Wang J. Caenorhabditis elegans RNA-processing Protein TDP-1 Regulates Protein Homeostasis and Lifespan. J Biol Chem. 2012 Jan 9. [Epub ahead of print]. PMID:22232551. PMCID: PMC3318719.Zuniga MG, Dinkes RE, Davalos-Bichara M, Carey JP, Schubert MC, King WM, Walston J, Agrawal Y. Association Between Hearing Loss and Saccular Dysfunction in Older Individuals. Otol Neurotol. 2012 Dec;33(9):1586-92. doi: 10.1097/MAO.0b013e31826bedbc. 2012 Oct 11. [Epub ahead of print]. PMID: 23064383. PMCID: PMC3498596.

2011

Abadir PM, Foster DB, Crow M, Cooke CA, Rucker JJ, Jain A, Smith BJ, Burks TN, Cohn RD, Fedarko NS, Carey RM, O’Rourke B, Walston JD. Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14849-54. Epub 2011 Aug 18. PMID:21852574. PMCID: PMC3169127.

Abadir PM. The frail renin-angiotensin system. Clin Geriatr Med. 2011 Feb;27(1):53-65. PMID:21093722.

Abadir PM, Walston JD, Carey RM, Siragy HM. Angiotensin II Type-2 Receptors Modulate Inflammation Through Signal Transducer and Activator of Transcription Proteins 3 Phosphorylation and TNF? Production. J Interferon Cytokine Res. 2011 Feb 2. [Epub ahead of print]. PMID: 21288138. PMCID: PMC3104285.

Agbedia OO, Varma VR, Seplaki CL, Seeman TE, Fried LP, Li L, Harris GC, Rebok GW, Xue QL, Tan EJ, Tanner E, Parisi JM, McGill S, Carlson MC. Blunted diurnal decline of cortisol among older adults with low socioeconomic status. Ann N Y Acad Sci. 2011 Aug;1231(1):56-64. doi: 10.1111/j.1749-6632.2011.06151.x. PMID:21884161. PMCID: PMC3369216.

Benke KS, Carlson MC, Doan BQ, Walston JD, Xue QL, Reiner AP, Fried LP, Arking DE, Chakravarti A, Fallin MD. The association of genetic variants in interleukin-1 genes with cognition: Findings from the cardiovascular health study. Exp Gerontol. 2011 Dec; 46(12):1010-9. Epub Sep 24. PMID:21968104.

Burks TN, Cohn RD. One size may not fit all: anti-aging therapies and sarcopenia. Aging (Albany NY). 2011 Dec;3(12):1142-53. PMID: 22184279. PMCID: PMC3273894.

Burks TN and Cohn RD. Role of TGF-b signaling in inherited and acquired myopathies. Skeletal Muscle. 2011 May 4;1(1):19. PMID:21798096. PMCID: PMC3156642.

Burks TN, Andres-Mateo, E. Marx R, Mejias R. Van Erp C, Simmers JL, Walston JD, Ward CW, Cohn RD. Losartan restores skeletal muscle remodeling and protects against disuse atrophy in sarcopenia. Sci Trans Med. 2011 May 11;3(82):82ra37. PMID:21562229. PMCID: PMC3140459.

Calvi CL, Podowski M, D’Alessio FR, Metzger SL, Misono K, Poonyagariyagorn H, Lopez-Mercado A, Ku T, Lauer T, Cheadle C, Talbot CC Jr, Jie C, McGrath-Morrow S, King LS, Walston J, Neptune ER. Critical transition in tissue homeostasis accompanies murine lung senescence. PLoS One. 2011;6(6):e20712. Epub 2011 Jun 21. PMID:21713037. PMCID: MPC3119663.

Eckel SP, Bandeen-Roche K, Chaves PH, Fried LP, Louis TA. Surrogate screening models for the low physical activity criterion of frailty. Aging Clin Exp Res. 2011 Jun;23(3):209-16. PMID: 21993168. PMCID: PMC3351838.

Ho YY, Matteini AM, Beamer BA, Fried LP, Xue Q-L, Arking DE, Chakravarti A, Walston JD, Fallin D. Exploring Biologically Relevant Pathways in Frailty. J Gerontol A Biol Sci Med Sci. 2011 September;66A(9):975–979. PMID: 21743092. PMCID: PMC3156628.

Kalyani RR, Varadhan R, Weiss CO, Fried LP, Cappola A. Frailty Status and Altered Glucose-Insulin Dynamics. Journal of Gerontology: Medical Sciences. 2011; 26 August [epub ahead of print] PMID: 21873592.

Leng SX, Tian X, Matteini A, Li H, Hughes J, Jain A, Walston JD, Fedarko NS. IL-6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults. Age Ageing. 2011 Jul;40(4):475-81. Epub 2011 May 17. PMID: 21586579. PMCID: PMC3114624.

Leng SX, Qu T, Semba RD, Li H, Yao X, Nilles T, Yang X, Manwani B, Walston JD, Ferrucci L, Fried LP, Margolick JB, Bream JH. Relationship between cytomegalovirus (CMV) IgG serology, detectable CMV DNA in peripheral monocytes, and CMV pp65(495-503)-specific CD8 (+) T cells in older adults. Age (Dordr). 2011 Dec; 33(4):607-14. Epub 2011 Jan 28. PMID: 21274637. PMCID: PMC3220402. 

Leng SX, Li HF, Xue Q-L, Yao X, Tian J, Yang X, Ferrucci L, Fedarko N, Fried LP, Semba RD. Association of detectable cytomegalovirus (CMV) DNA in monocytes rather than positive CMV IgG serology with elevated neopterin levels in community-dwelling older adults. Exp Gerontol2011 Aug;46(8):679-84. Epub 2011 Apr 13. PMID: 21513787. PMCID: PMC31314158.

Lin FR, Thorpe R, Gordon-Salant S, Ferrucci L. Hearing Loss Prevalence and Risk Factors Among Older Adults in the United States. J Gerontol A Biol Sci Med Sci. 2011 May;66(5):582-90. Epub 2011 Feb 27. PMID: 21357188. PMCID: PMC3074958. 

Leoutsakos JM, Bandeen-Roche K, Garrett-Mayer E, Zandi PP. Incorporating scientific knowledge into phenotype development: Penalized latent class regression. Stat Med. 2011 Mar 30;30(7):784-98. PMID: 21394753.

Moseley KF, Dobrosielski DA, Stewart Kj, Jan De Beur SM, Sellmeyer DE. Lean mass and fat mass predict bone mineral density in middle-aged individuals with non-insulin -requiring type 2 diabetes mellitus. Clin Endocrinol (Oxf). 2011 May;74(5):565-71. doi: 10.1111/j.1365-2265.2010.03965.x. Epub 2010 Dec 24.

Neufeld KJ, Joseph Bienvenu O, Rosenberg PB, Mears SC, Lee HB, Kamdar BB, Sieber FE, Krumm SK, Walston JD, Hager DN, Touradji P, Needham DM. The Johns Hopkins Delirium Consortium: a model for collaborating across disciplines and departments for delirium prevention and treatment. J Am Geriatr Soc. 2011 Nov;59 Suppl 2:S244-8. doi: 10.1111/j.1532-5415.2011.03672.x. PMID:22091568[PubMed – indexed for MEDLINE]. PMC Journal- In Process.

Reinke C, Bevans-Fonti S, Grigoryev DN, Drager LF, Myers AC, Wise RA, Schwartz AR, Mitzner W, Polotsky VY. Chronic intermittent hypoxia induces lung growth in adult mice. Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L266-73. Epub 2010 Dec 3. PMID:21131398. PMCID: PMC3043819.

Roy CN. Anemia in frailty. Clin Geriatr Med. 2011 Feb;27(1):67-78. PMID:21093723. PMCID: PMC2998908.

Szanton SL, Thorpe RJ, Boyd C, Tanner EK, Leff B, Agree E, Xue QL, Allen JK, Seplaki CL, Weiss C, Guralnik JM, Gitlin LN. CAPABLE: A bio-behavioral-environmental intervention to improve function and health-related quality of life in disabled, older adults. J Am Geriatr Soc. 2011 Dec;59(12):2314-20. PMID: 22091738. PMCID: PMC3245364.

Walston JD. Frailty. Preface. Clin Geriatr Med. 2011 Feb;27(1):xi. No abstract available. PMID:21093717.

Weiss CO. Frailty and chronic diseases in older adults. Clin Geriatr Med. 2011 Feb;27(1):39-52. Review. PMID:21093721.

Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011 Feb;27(1):1-15. Review. PMID:21093718. PMCID: PMC3028599.

Xue Q-L, Walston JD, Fried LP, Beamer BA. Prediction of risk of falling, physical disability, and frailty by rate of decline in grip strength: The Women’s Health and Aging Study. Arch Intern Med. 2011 Jun 27;171(12):1119-21. No abstract available. PMID:21709116.

Yao X, Hamilton R, Weng N-P, Xue Q-L, Bream JH, Tian J, Yeh S-H, Resnick B, Xu XY, Walston JD, Fried LP, Leng SX. Frailty is associated with poor vaccine-induced antibody response and increased influenza infection in community-dwelling older adults. Vaccine. 2011 Jul 12;29(31):5015-21. Epub 2011 May 10. PMID:21565245. PMCID: PMC3129421.

Yao X, Li H, Leng SX. Inflammation and immune system alterations in frailty. Clin Geriatr Med. 2011 Feb;27(1):79-87. PMID: 21093724. PMCID: PMC3011971.Zhang T, Mullane PC, Periz G, Wang J. TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling. Hum Mol Genet. 2011 May 15; 20(10):1952-65. Epub 2011 Feb 25. PMID: 21355045. PMCID: PMC3080607.

2010

Crentsil V. Mechanistic contribution of carnitine deficiency to geriatric frailty. Ageing Res Rev. 2010 Jul;9(3):265-8. Epub 2010 Mar 17. PMID: 20223299.

Crentsil V, Ricks MO, Xue QL, Fried LP. A pharmacoepidemiologic study of community-dwelling, disabled older women: Factors associated with medication use. Am J Geriatr Pharmacother. 2010 Jun;8(3):215-24. PMID: 20624611.

Franckowiak SC, Dobrosielski DA, Reilley SM, Walston JD, Andersen RE. Maximal Heart Rate Prediction in Adults that are Overweight or Obese. J Strength Cond Res. 2010 Nov 24. [Epub ahead of print]. PMID: 21116203.

Makary MA, Segev DL, Fried LP, Syin D, Bandeen-Roche K, Patel P, Devgan L, Holzmueller CG, Tian J, Pronovost PR. Frailty as a Predictor of Surgical Outcome in Older Patients. J Am Coll Surg. 2010 Jun;210(6):901-8. Epub 2010 Apr 28. PMID: 20510798.

Matteini AM, Walston JD, Bandeen-Roche K, Arking DE, Allen RH, Fried LP, Chakravarti A, Stabler SP, Fallin MD.  Transcobalamin-II variants, decreased vitamin B12 availability and increased risk of frailty.  J Nutr Health Aging. 2010 Jan;14(1):73-7.  PMID: 20082058.

Matteini AM, Fallin MD, Kammerer CM, Schupf N, Yashin AI, Christensen K, Arbeev KG, Barr G, Mayeux R, Newman AB, Walston JD. Heritability Estimates of Endophenotypes of Long and Health Life: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2010 Sep 2. [Epub ahead of print]. PMID: 20813793.

Mielke MM, Bandaru VV, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2010 Jan;31(1):17-24. doi: 10.1016/j.neurobiolaging.2008.03.011. Epub 2008 May 5. PMID: 18455839

Moore AZ, Biggs ML, Matteini AM, O’Connor A, McGuire S, Beamer B, Fallin MD, Fried LP, Walston J, Chakravarti A, Arking DE. Polymorphisms in the mitochondrial DNA control region and frailty in older adults.  PLoS One. 2010 Jun 10;5(6):e11069. PMID: 20548781. PMCID: PMC2883558.

Rosenberg PB, Mielke MM, Xue QL, Carlson MC.  Depressive symptoms predict incident cognitive impairment in cognitive healthy older women.  Am J Geriatr Psychiatry. 2010 Mar;18(3):204-11.  PMID: 20224517.

Roy CN.  Anemia of inflammation.  Hematology Am Soc Hematol Educ Program. 2010;2010:276-80. PMID: 21239806.

Semba RD, Patel KV, Ferrucci L, Sun K, Roy CN, Guralnik JM, Fried LP. Serum antioxidants and inflammation predict red cell distribution width in older women: The Women’s Health and Aging Study I. Clin Nutr. 2010 Oct;29(5):600-4. 2010 Mar 22. [Epub ahead of print] PMID: 20334961

Sourial N, Wolfson C, Bergman H, Zhu B, Karunananthan S, Quail J, Fletcher J, Weiss D, Bandeen-Roche K, Béland F. A correspondence analysis revealed frailty deficits aggregate and are multidimensional. J Clin Epidemiol. 2010 Jun;63(6):638-46. Epub 2009 Nov 6.

Sourial N, Wolfson C, Zhu B, Quail J, Fletcher J, Karunananthan S, Bandeen-Roche K, Béland F, Bergman H. Correspondence analysis is a useful tool to uncover the relationships among categorical variables. J Clin Epidemiol. 2010 Jun;63(6):647-54. Epub 2009 Oct 31.

Tanaka T, Roy CN, Yao W, Matteini A, Semba RD, Arking D, Walston JD, Fried LP, Singleton A, Guralnik J, Abecasis GR, Bandinelli S, Longo DL, and Ferrucci L. A Genome-Wide Association Analysis of Serum Iron Concentrations. Blood 2010; 115(1):94-96. PMID: 19880490

Varadhan R, Weiss CO, Segal JB, Wu AW, Scharfstein D, Boyd C. Evaluating health outcomes in the presence of competing risks: a review of statistical methods and clinical applications. Med Care. 2010 Jun;48(6 Suppl):S96-105. PMID: 20473207

Wang GC, Talor MV, Rose NR, Cappola AR, Chiou RB, Weiss C, Walston JD, Fried LP, Caturegli P. Thyroid autoantibodies are associated with a reduced prevalence of frailty in community-dwelling older women. J Clin Endocrinol Metab. 2010 Mar;95(3):1161-8. Epub 2010 Jan 8.  PMID: 20061418.

Wang GC, Kao WH, Murakami P, Xue QL, Chiou RB, Detrick B, McDyer JF, Semba RD, Casolaro V, Walston JD, Fried LP. Cytomegalovirus Infection and the Risk of Mortality and Frailty in Older Women: A Prospective Observational Cohort Study. Am J Epidemiol. 2010 May 15;171(10):1144-52. Epub 2010 Apr 16. PMID: 20400465.

Weiss CO, Hoenig HH, Varadhan R, Simonsick EM, Fried LP. Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women. J Gerontol A Biol Sci Med Sci. 2010 Mar;65(3):287-94. Epub 2009 Oct 12. PMID: 19822621. Xue QL, Beamer BA, Chaves PH, Guralnik JM, Fried LP. Heterogeneity in rate of decline in grip, hip, and knee strength and the risk of all-cause mortality: the Women’s Health and Aging Study II.J Am Geriatr Soc. 2010 Nov;58(11):2076-84. PMID:21054287.

2009

Alipanah N, Varadhan R, Sun K, Ferrucci L, Fried LP, Semba RD. Low serum carotenoids are associated with a decline in walking speed in older women. J Nutr Health Aging. 2009 Mar;13(3):170-5. PMID: 19262947.

Bandeen-Roche K, Walston JD, Huang Y, Semba RD, Ferrucci L. Measuring systemic inflammatory regulation in older adults: evidence and utility. Rejuvenation Res. 2009 Dec;12(6):403-10. PMID: 20041734

Boyd C, Ricks M, Fried LP, Guralnik JM, Xue Q-L, Xia J, Bandeen-Roche K. Functional Decline And Recovery of Activities of Daily Living among Hospitalized, Disabled Older Women: The Women’s Health and Aging Study I. J Am Geriatr Soc. 2009 Aug 20. [Epub ahead of print]. PMID: 19694869

Cappola AR, Xue QL, Fried LP. Multiple hormonal deficiencies in anabolic hormones are found in frail older women: the Women’s Health and Aging studies. J Gerontol A Biol Sci Med Sci. 2009 Feb;64(2):243-8. Epub 2009 Jan 31. PMID: 19182229

Carlson MC, Xue QL, Zhou J, & Fried LP. Executive Decline and Dysfunction Precedes Declines in Memory: The Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):110-7. Epub 2009 Jan 31. PMID: 19182230.

Carlson MC, Erickson KI, Kramer AF, Voss MW, Bolea N, Mielke M, McGill S, Rebok GW, Seeman T, Fried LP. Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci. 2009 Dec;64(12):1275-82. Epub 2009 Aug 19. PMID: 19692672

Chang SS, Weiss CO, Xue QL, Fried LP. Patterns of comorbid inflammatory diseases in frail older women: the Women’s Health and Aging Studies I and II. J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):407-13. Epub 2009 Nov 23. PMID: 19933749.

Deal JA, Carlson MC, Xue QL, Fried LP, Chaves PH. Anemia and 9-year domain-specific cognitive decline in community-dwelling older women: The Women’s Health and Aging Study II. J Am Geriatr Soc. 2009 Sep;57(9):1604-11. Epub 2009 Aug 13. PMID: 19682133.

Ferrucci L, Perry JR, Matteini A, Perola M, Tanaka T, Silander K, Rice N, Melzer D, Murray A, Cluett C, Fried LP, Albanes D, Corsi AM, Cherubini A, Guralnik J, Bandinelli S, Singleton A, Virtamo J, Walston J, Semba RD, Frayling TM. Common variation in the beta-carotene 15,15′-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. Am J Hum Genet. 2009 Feb;84(2):123-33. Epub 2009 Jan 29. PMID: 19185284.

Fallin MD, Matteini A. Genetic Epidemiology in Aging Research. class=”journalname”J Gerontol A Biol Sci Med Sci. 2009 Jan;64(1):47-60. Epub 2009 Jan 23. PMID: 19168782.

Fried LP, Xue QL, Cappola AR, Ferrucci L, Chaves P, Varadhan R, Guralnik JM, Leng SX, Semba RD, Walston JD, Blaum CS, Bandeen-Roche K. Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment. J Gerontol A Biol Sci Med Sci. 2009 Oct;64(10):1049-57. Epub 2009 Jun 30. PMID: 19567825.

Hsiao CJ, Bandeen-Roche K, Marsteller JA, Leff BA. The effect of disability on personal quality of primary care received by older adults. Disabil Rehabil. 2009;31(22):1835-42. PMID: 19479548.

Leng SX, Hung W, Cappola AR, Yu Q, Xue QL, Fried LP. White Blood Cell Counts, Insulinlike Growth Factor-1 Levels, and Frailty in Community-Dwelling Older Women. J Gerontol A Biol Sci Med Sci. 2009 Apr;64(4):499-502. Epub 2009 Feb 27. PMID: 19251912.

Leng SX, Xue QL, Tian J, Huang Y, Yeh SH, Fried LP. Associations of neutrophil and monocyte counts with frailty in community-dwelling disabled older women: results from the Women’s Health and Aging Studies I. Exp Gerontol. 2009 Aug;44(8):511-6. Epub 2009 May 18. PMID: 19457449.

Mielke MM, Kozauer NA, Chan KC, George M, Toroney J, Zerrate M, Bandeen-Roche K, Wang MC, Vanzijl P, Pekar JJ, Mori S, Lyketsos CG, Albert M. Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer’s disease. Neuroimage. 2009 May 15;46(1):47-55. Epub 2009 Feb 5. PMID: 19457371.

Qu T, Yang H, Walston JD, Fedarko NS, Leng SX. Upregulated monocytic expression of CXC chemokine ligand 10 (CXCL-10) and its relationship with serum interleukin-6 levels in the syndrome of frailty. Cytokine. 2009 Jun;46(3):319-24. Epub 2009 Apr 1. PMID: 19342252.

Semba RD, Ferrucci L, Sun K, Beck J, Dalal M, Varadhan R, Walston J, Guralnik JM, Fried LP. Advanced glycation end products and their circulating receptors predict cardiovascular disease mortality in older community-dwelling women. Aging Clin Exp Res. 2009 Apr;21(2):182-90. PMID: 19448391.

Szanton, S.L., Allen JK, Seplaki, CL, Bandeen-Roche K, Fried LP. Allostatic Load and Frailty in the Women’s Health and Aging Studies. Biol Res Nurs. 2009 Jan;10(3):248-56. Epub 2008 Sep 30. PMID: 18829589.

Tan EJ, Rebok GW, Yu Q, Frangakis CE, Carlson MC, Wang T, Ricks M, Tanner EK, McGill S, Fried LP. The Long-Term Relationship Between High-Intensity Volunteering and Physical Activity in Older African American Women. J Gerontol B Psychol Sci Soc Sci. 2009 Mar;64(2):304-11. Epub 2009 Jan 29. PMID: 19181687.

Thorpe RJ Jr, Weiss C, Xue QL, Fried LP. Transitions among disability levels or death in African American and white older women. J Gerontol A Biol Sci Med Sci. 2009 Jun;64(6):670-4. Epub 2009 Feb 19. PMID: 19228790.

Varadhan R, Chaves PH, Lipsitz LA, Stein PK, Tian J, Windham BG, Berger RD, Fried LP. Frailty and Impaired Cardiac Autonomic Control: New Insights From Principal Components Aggregation of Traditional Heart Rate Variability Indices. J Gerontol A Biol Sci Med Sci. 2009 Jun;64(6):682-7. Epub 2009 Feb 17. PMID: 19223607.

Varadhan R, Gilbert P. BB: An R Package for Solving a Large System of Nonlinear Equations and for Optimizing a High-Dimensional Nonlinear Objective Function. J Stat Soft. 2009 Oct;32(4):1-26.

Walston JD, Matteini AM, Nievergelt C, Lange LA, Fallin DM, Barzilai N, Ziv E, Pawlikowska L, Kwok P, Cummings SR, Kooperberg C, Lacroix A, Tracy RP, Atzmon G, Lange EM, Reiner AP. Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults. Exp Gerontol. 2009 May;44(5):350-5. Epub 2009 Feb 26. PMID: 19249341. Xue, Q-L, Bandeen-Roche K. Latent variable regression analysis with missing covariates. Koln, Germany: Lambert Academic Publishing AG& Co. KG; 2009.

2008

Carlson MC, Helms MJ, Steffens DC, Burke JR, Potter GG, Plassman BL. Mid-life Activity Predicts Risk of Alzheimer’s Disease in Older Male Twin Pairs.  Alzheimers Dement. 2008 Sep;4(5):324-31.PMID: 18790459.

Dayhoff-Brannigan M, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD. Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community. J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):179-83. PMID: 18314454

De Fanis U, Wang G, Fedarko N, Walston J, Casolaro V, and Leng SX. T-lymphocytes expressing CC chemokine receptor-5 are increased in frail older adults. J Am Geriatr Soc.2008 May;56(5):904-8. Epub 2008 Apr 1. PMID: 18384587.

Espinoza SE, Guo H, Fedarko N, DeZern A, Fried LP, Xue QL, Leng S, Beamer B, Walston JD. Glutathione peroxidase enzyme activity in aging. J Gerontol A Biol Sci Med Sci. 2008 May;63(5):505-9. PMID: 18511755.

Evans WJ, Bhasin S, Cress C, Espeland MA, Ferrucci L, Fried LP, Gill G, Pahor M, Studenski S (Working Group on Functional Outcome Measures for Clinical Trials). Functional outcomes for clinical trials in frail older persons: time to be moving. J Gerontol A Biol Sci Med Sci. 2008 Feb;63(2):160-4. PMID: 18314451.

Matteini AM, Walston JD, Fallin MD, Bandeen-Roche K, Kao WHL, Semba RD, Allen RH, Guralnik J, Fried LP, Stabler SP. Markers of B-vitamin deficiency and frailty in older women. J Nutr Health Aging. 2008 May;12(5):303-8. PMID: 18443711.

Mielke MM, Xue QL, Zhou J, Chaves PH, Fried LP, Carlson MC. Baseline Serum Cholesterol Is Selectively Associated With Motor Speed and Not Rates of Cognitive Decline: The Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 Jun;63(6):619-24.

Swihart BJ, Caffo B, Bandeen-Roche K, Punjabi NM. Characterizing sleep structure using the hypnogram. J Clin Sleep Med. 2008 Aug 15;4(4):349-55. PMID: 18763427.

Varadhan R, Seplaki CL, Xue QL, Bandeen-Roche K, Fried LP. Stimulus-response paradigm for characterizing the loss of resilience in homeostatic regulation associated with frailty. Mech Ageing Dev. 2008 Nov;129(11):666-70. Epub 2008 Sep 30.PMID: 18938195.

Varadhan R, Walston J, Cappola AR, Carlson MC, Wand GS, Fried LP. Higher Levels and Blunted Diurnal Variation of Cortisol in Frail Older Women. J Gerontol A Biol Sci Med Sci2008 63: 190-195.

Varadhan R., Roland C. Simple and globally-convergent methods for accelerating the convergence of any EM algorithm. Scandinavian Journal of Statistics, Danish Society for Theoretical Statistics, Finnish Statistical Society, Norwegian Statistical Association and Swedish Statistical Association, vol. 35(2), pages 335-353.

Walston J, Fedarko N, Yang H, Leng S, Beamer B, Espinoza S, Lipton A, Zheng H, Becker K. The physical and biological characterization of a frail mouse model. J Gerontol A Biol Sci Med Sci. 2008 Apr;63(4):391-8. PMID: 18426963.

Weiss CO, Seplaki CL, Wolff JL, Kasper JD, Agree EM. Self-selected walking speed was consistent when recorded while using a cane. J Clin Epidemiol. 2008 Jun;61(6):622-7. doi: 10.1016/j.jclinepi.2007.07.020. Epub 2008 Mar 10. PMID: 18471668

Xue Q-L, Fried LP, Glass TA, Laffan AM, Chaves PHM. Life-space constriction, development of frailty, and the competing risk of mortality: the Women’s Health And Aging Study I. Am J Epidemiol. 2008 Jan 15;167(2):240-8. Epub 2007 Sep 28. PMID: 17906296. Xue Q-L, Bandeen-Roche K, Zhou J, Varadhan R, Fried LP. Initial manifestations of frailty criteria and the development of frailty phenotype in the Women’s Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 Sep;63(9):984-90.PMID: 18840805.

2007

Barzilay JI, Blaum C, Moore T, Xue Q-L, Hirsch CH, Walston JD, Fried LP. Insulin Resistance and Inflammation as Precursors of Frailty: The Cardiovascular Health Study. Arch Intern Med 2007; 167(7):635-41. PMID: 17420420.

Beck J, Ferrucci L, Sun K, Walston J, Fried LP, Varadhan R, Guralnik JM, Semba RD. Low serum selenium concentrations are associated with poor grip strength among older women living in the community. Biofactors. 2007;29(1):37-44. PMID: 17611292.

Boyd CM, Weiss CO, Halter J, Han KC, Ershler WB, Fried LP: Framework for Evaluating Disease Severity Measures in Older Adults with Comorbidity. J Gerontol A Biol Sci Med Sci. 2007, Vol. 62A, No. 3, 286–295. PMID: 17389726.

Chang DC, Joyce DL, Shoher A, Yuh DD. A Simple Index to Predict Likelihood of Skilled Nursing Facility Admission after CABG among Older Patients. Ann Thorac Surg. 2007 Sep;84(3):829-34; discussion 834-5. PMID: 17720384

Desquilbet L, Jacobson LP, Fried LP, Phair JP, Jamieson BD, Holloway M, Margolick JB; Multicenter AIDS Cohort Study. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007 Nov;62(11):1279-86. PMID: 18000149.

Folsom AR, Boland LL, Cushman M, Heckbert SR, Rosamond WD, Walston JD. Frailty and risk of venous thromboembolism in older adults. J Gerontol A Biol Sci Med Sci. 2007 Jan;62(1):79-82. PMID: 15066083.

Howard C, Ferrucci L, Sun K, Fried LP, Walston J, Varadhan R, Guralnik JM, Semba RD. Oxidative protein damage is associated with poor grip strength among older women living in the community. J Appl Physiol. 2007 Jul;103(1):17-20. Epub 2007 Mar 22. PMID: 17379753.

Leng SX, Xue Q-L, Tian J, Walston J, Fried LP. Inflammation and frailty in older women. J Am Geriatr Soc. 2007 Jun;55(6):864-71. PMID: 17537086.

Rebok GW, Carlson MC, & Langbaum JB. Training and maintaining memory abilities in healthy older adults: traditional and novel approaches. J Gerontol B Psychol Sci Soc Sci.2007 Jun;62 Spec No 1:53-61. Review. PMID: 17565165.

Roland C., Varadhan R., and Frangakis C.E. Squared polynomial extrapolation methods with cycling: an application to the positron emission tomography problem, Numerical Algorithms, Volume 44, Number 2, February 2007, pp. 159-172.

Semba RD, Ferrucci L, Sun K, Walston J, Varadhan R, Guralnik JM, Fried LP. Oxidative stress and severe walking disability among older women. Am J Med. 2007 Dec;120(12):1084-9. PMID: 18060930.

Semba RD, Ricks MO, Ferrucci L, Xue QL, Guralnik JM, Fried LP. Low serum selenium is associated with anemia among older adults in the United States. Eur J Clin Nutr. 2007 Sep 5; [Epub ahead of print]. PMID: 17805227.

Walston JD, Fallin MD, Cushman M, Lange L, Psaty B, Jenny N, Browner W, Tracy R, Durda P, Reiner A. IL-6 gene variation is associated with IL-6 and C-reactive protein levels but not cardiovascular outcomes in the Cardiovascular Health Study. Hum Genet.2007 Dec;122(5):485-94. Epub 2007 Sep 13. PMID: 17851695.

Weiss CO, Boyd CM, Yu Q, Wolff JL, Leff B. Patterns of prevalent major chronic disease among older adults in the United States. JAMA. 2007 Sep 12;298(10):1160-2. PMID: 17848649.

2006

Arking DE, Fallin DM, Li T, Beamer BA, Xue QL, Fried LP, Chakravarti A, Walston JD. Variation in the Ciliary Neurotrophic Factor Gene and Muscle Strength in Older Caucasian Women. Journal of the American Geriatrics Society, 2006; May;54(5):823-6. PMID: 16696750.

Bandeen-Roche K, Xue Q-L, Ferrucci L, Walston J, Guralnik JM, Chaves PHM, Zeger SL, Fried LP. Phenotype of Frailty: Characterization in the Women’s Health and Aging Studies. J GerontolMed Sci, 2006 Mar;61(3):262-6. PMID: 16567375.

Bartali B, Frongillo EA, Bandinelli S, Lauretani F, Semba RD, Fried LP, Ferrucci L. Low nutrient intake is an essential component of frailty in older persons. J Gerontol: Med Sci.2006 Jun;61(6):589-93. PMID: 16799141.

Chaves PHM, Carlson MC, Guralnik JM, Ferrucci L, Semba R, Fried LP. Association of Mild Anemia with Executive Cognitive Function Impairment in Community-Dwelling Older Women: The Women’s Health and Aging Study II. J Am Geriatr Soc. 2006 Sep;54(9):1429-35. PMID: 16970654.

Chi PB, Duggal P, Kao WH, Mathias RA, Grant AV, Stockton ML, Garcia JG, Ingersoll RG, Scott AF, Beaty TH, Barnes KC, Fallin MD. Comparison of SNP tagging methods using empirical data: association study of 713 SNPs on chromosome 12q14.3-12q24.21 for asthma and total serum IgE in an African Caribbean population. Genet Epidemiol. 2006 Nov: 30(7):609-19. PMID: 16830339.

Kim DH, Lipsitz LA, Ferrucci L, Guralnik JM, Carlson M, Fleisher LA, Fried LP, Chaves PHM. Association of Reduced Heart Rate Variability with Cognitive Impairment in Older Disabled Women in the Community: A Pilot Study in the Women’s Health and Aging Study I. J Am Geriatr Soc. 2006 Nov;54(11):1751-7. PMID: 17087704.

Ling SM, Xue QL, Simonsick EM, Tian J, Bandeen-Roche K, Fried LP, Bathon JM. Transitions to mobility difficulty associated with lower extremity osteoarthritis in high functioning older women: longitudinal data from the Women’s Health and Aging Study II.Arthritis Rheum. 2006 Apr 15;55(2): 256-63. PMID: 16583416.

Michelon E, Blaum C, Semba RD, Xue QL, Ricks MO, Fried LP. Vitamin and carotenoid status in older women: associations with the frailty syndrome. J Gerontol A Biol Sci Med Sci. 2006 Jun;61(6):600-7. PMID: 16799143.

Studenski S, Carlson MC, Fillit H, Greenough WT, Kramer A, Rebok GW.. From bedside to bench: does mental and physical activity promote cognitive vitality in late life? Sci Aging Knowledge Environ 2006. 28; (10): 21. PMID: 16807485.

Tan EJ, Xue QL, Li T, Carlson MC, Fried LP. Volunteering: a physical activity intervention for older adults–The Experience Corps program in Baltimore.J Urban Health. 2006 Sep;83(5):954-69. PMID: 16763775.

Walston J, Hadley EC, Ferrucci L, Guralnik J, Newman, AB, Studenski S, Ershler W, Harris T, Fried LP. Research agenda for Frailty in Older Adults: Towards a Better Understanding of Physiology and Etiology. J Am Geriatr Soc. 2006 Jun;54(6):991-1001. PMID: 16776798. Walston J, Xue Q-L, Semba RD, Ferrucci L, Cappola AR, Ricks M, Guralnik JM, Fried LP. Serum Antioxidants, Inflammation, and Mortality in Older Women. American Journal of Epidemiology 2006:Jan1;163(1):18-26. PMID: 16306311.

2005

Benke KS, Chase GA, Fallin D. Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test. BMC Genet. 2005 Dec 30;6 Suppl 1:S137. PMID: 16451596

Blaum CS, Xue Q-L, Michelon E, Semba RD, Fried LP. The association of obesity and the frailty syndrome in older women. The Journal of the American Geriatrics Society 2005 June; 53(6):927-34. PMID: 15935013.

Boyd CM, Darer J, Boult C, Fried LP, Boult L, Wu A. Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance. JAMA, August 10, 2005:294:5:716-724. PMID: 16091574.

Boyd CM, Xue Q-L, Simpson CF, Guralnik JM, Fried LP. Frailty, hospitalization and progression of disability in a cohort of disabled older women: The Women’s Health and Aging Study I. The American Journal of Medicine, 2005 Nov;118(11):1225-31. PMID: 16271906.

Chaves PH, Semba RD, Leng SX, Woodman RC, Ferrucci L, Guralnik JM, Fried LP. Impact of Anemia and Cardiovascular Disease on Frailty Status of Community-Dwelling Older Women: The Women’s Health and Aging Studies I and II. J Gerontol Med Sci, 2005 June;60A:6:729-735. PMID: 15983175.

Fried LP, Hadley EC, Walston JD, Newman A, Guralnik JM, Studenski S, Harris TB, Ershler WB, Ferrucci L. From bedside to bench: research agenda for frailty. Sci Aging Knowledge Environ. 2005 Aug 3;2005(31):pe24. PMID: 16079413.

Leng SX, Xue Q-L, Huang Y, Ferrucci L, Beamer BA, Fried LP, Walston J. Baseline Total and Specific Differential White Blood Cell Counts and 5-year All-Cause Mortality in Community-Dwelling Older Women. Experimental Gerontology, 2005 Dec, (40):982-987. PMID: 16183235.

Leng SX, Xue Q-L, Huang Y, Semba R, Chaves P, Bandeen-Roche K, Fried LP, Walston J. Total and differential WBC counts and their associations with circulating IL-6 levels in community-dwelling older women. J Gerontol Med Sci, 2005;60A:195-199.

Nicodemus KK, Liu W, Chase GA, Tsai YY, Fallin MD. Comparison of type I Error for Multiple Test Corrections in Large SNP Studies Using Principal Components Versus Haplotype Blocking Algorithms. BMC Genetics 2005 Dec: 6 Suppl 1:S78. PMID: 16451692

Walston J, Arking DE, Fallin D, Li T, Beamer B, Xue Q, Ferrucci L, Fried LP, Chakravarti A. IL-6 Gene Variation is not Associated with Increased Serum Levels of IL-6, muscle weakness, or frailty in older women. Experimental Gerontology, 2005; 40:344-352. PMID: 15820616.

Wang C-P, Brown CH, Bandeen-Roche K. Residual Diagnostics for Growth Mixture Models: Examining the Impact of a Preventive Intervention on Multiple Trajectories of Aggressive Behavior. Journal of the American Statistical Association, 2005 Sep;100(3):1054-1076. Yuh DD, Baumgartner WA. Cardiac Surgery in the Elderly. In: Gerstenblith G, ed. Cardiovascular Disease in the Elderly. Totowa, NJ, Humana Press, Inc. 2005 June: pp. 179-201.

2004

Bjornsson HT, Cui H, Guis D, Fallin MD, Feinberg AP. The New Field of Epigenomics: Implications for Cancer and Other Common Disease Research. Cold Spring Harb Symp Quant Biol. 2004: 69:447-56. PMID: 16117680.

Bjornsson HT, Fallin MD, Feinberg AP. An integrated epigenetic and genetic approach to common human disease. Trends Genet. 2004 Aug: 20(8):350-8. PMID: 15262407.

Ferrucci L, Guralnik JM, Studenski S, Fried LP, Cutler GB Jr, Walston JD (Interventions on Frailty Working Group). Designing randomized, controlled trials aimed at preventing or delaying functional decline and disability in frail, older persons: a consensus report. J Am Geriatr Soc. 2004 Apr;52(4):625-34. PMID: 15066083.

Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63. PMID: 15031310.