Characterization of Dynamic Adaptation to Stressors using Multi-System Stimulus-Response Data: The Study of Physical Resilience in Aging Pilot Design Implications for Local Linear Approximation of Dynamical Physiological Systems Data A Taxonomy to Characterize Stressor Variation in Studies of Physical Resilience and its Validation in Total Knee Replacement Multivariate Profiling of Physical Resilience in Older Adults […]
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Frailty Educational Video Modules
The Johns Hopkins University (JHU) Older Americans Independence Center (OAIC) and FrailtyScience.org are pleased to offer a series of educational video modules on the science of frailty.
Request For Letters Of Intent (LOI)
THIS CALL FOR LETTERS IS NOW CLOSED. JHU OAIC Awards, Grant Year 2025-2026 LOI Due Date: March 15, 2025 . Download PDF Instructions here. The National Institute on Aging-supported Johns Hopkins Claude D. Pepper Older Americans Independence Center (OAIC; https://peppercenter.jhu.edu/) is soliciting Letters of Intent (LOI) for scientific projects related to physical frailty in older […]
The JHU OAIC collaboration initiative, known as the Pepper Scholars Program, consists primarily of monthly research-in-progress sessions that allow for OAIC-supported investigator interaction and discourse, along with progress updates and access to mentors and methodological experts. The program’s research-in-progress centerpiece is bolstered by an online collaboration tool, an ongoing seminar series, grant review sessions, and research facilitation […]
Frailty syndrome is defined as a clinically recognizable state of increased vulnerability resulting from aging-associated declines in reserve and function across multiple physiologic systems, so that the ability to cope with everyday or acute stressors is compromised. In the United States, frailty syndrome affects 15% of the older non-nursing home population aged 65 and older […]
Pilot and Exploratory Studies Core
The overall goal of Pilot and Exploratory Studies Core (PESC) is to cultivate and support cutting edge pilot and exploratory studies that will advance the development of effective prevention and/or therapies for frailty and hence facilitate independence in older adults. The PESC provides funding, access to biostatistical, biological, and clinical research core resources, and mentoring […]
The primary purpose of the Research Education Component (REC), formerly known as the Research Career Development Core (RCDC), is to increase the workforce of experts dedicated to scholarship on frailty and its translation into strategies to increase independence in older adults. The REC accomplishes this by identifying and selecting outstanding junior faculty investigators to pursue […]
Leadership and Administrative Core
The Leadership and Administrative Core (LAC) spearheads the collaborative mission and vision of the JHU Older Americans Independence Center (OAIC). The LAC serves as the driving force in identifying the next generation of research on frailty, supports research planning and recruitment of investigators, and sets and monitors progress benchmarks. The core administrates the OAIC and […]
Resource Core 1: Biostatistics Core
The Biostatistics Core (OAIC Resource Core 1, or RC1), seeks to empower our institutions’ scientists with the quantitative support and expertise needed to create and translate into clinical practice the next generations of research on frailty. The functions supplied by the Biostatistics Core of the Johns Hopkins Older Americans Independence Center have been central in […]
Resource Core 2: Biological Mechanisms Core
The rationale for the Biological Mechanisms Core (Resource Core 2, or RC2) is to provide the expertise, technology access and infrastructure, mentoring, and training necessary to facilitate the highest quality etiologic research in frailty. RC2-supported projects have made substantial scientific progress towards the elucidation of biological pathways critical to frailty and to highlighting biological pathways […]